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CAS 42924-53-8

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Nabumetone

Description:
Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID) primarily used for the treatment of osteoarthritis and rheumatoid arthritis. It is characterized by its analgesic and anti-inflammatory properties, which are attributed to its ability to inhibit cyclooxygenase (COX) enzymes, thereby reducing the synthesis of prostaglandins involved in inflammation and pain. Nabumetone is unique among NSAIDs as it is a prodrug, meaning it is metabolized in the liver to its active form, 6-methoxy-2-naphthylacetic acid. This metabolic conversion allows for a potentially lower incidence of gastrointestinal side effects compared to traditional NSAIDs. The substance is typically administered orally and is known for its relatively long half-life, allowing for once-daily dosing. Common side effects may include gastrointestinal discomfort, headache, and dizziness, while more serious risks involve cardiovascular and renal complications. As with all NSAIDs, it is important for patients to use nabumetone under medical supervision, particularly those with pre-existing health conditions.
Formula:C15H16O2
InChI:InChI=1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3
InChI key:InChIKey=BLXXJMDCKKHMKV-UHFFFAOYSA-N
SMILES:C(CC(C)=O)C1=CC2=C(C=C(OC)C=C2)C=C1
Synonyms:
  • 1-(2′-Methoxynaphth-6′-yl)butan-3-one
  • 2-Butanone, 4-(6-methoxy-2-naphthalenyl)-
  • 4-(6-Methoxy-2-naphthalenyl)-2-butanone
  • 4-(6-Methoxy-2-naphthyl)-2-butanone
  • 4-(6-Methoxynaphthalen-2-Yl)Butan-2-One
  • Arthaxan
  • Balmox
  • Brl 14777
  • Consolan
  • Coxalgan
  • See more synonyms
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