CAS 4294-45-5

DL-threo-β-Hydroxyaspartic acid

Description:

DL-threo-β-Hydroxyaspartic acid, with the CAS number 4294-45-5, is an amino acid derivative that serves as a structural analog of aspartic acid. This compound is characterized by the presence of a hydroxyl group (-OH) attached to the beta carbon of the aspartic acid backbone, which influences its biochemical properties and interactions. It exists as a racemic mixture of two enantiomers, contributing to its classification as "DL-threo." The substance is soluble in water, making it suitable for various biochemical applications, including studies related to neurotransmission and metabolic pathways. Its structural similarity to aspartate allows it to interact with glutamate receptors, potentially influencing excitatory neurotransmission in the central nervous system. Additionally, DL-threo-β-Hydroxyaspartic acid is of interest in research related to neuropharmacology and may have implications in understanding certain neurological disorders. As with many amino acid derivatives, it is important to handle this compound with care in laboratory settings, adhering to safety protocols to mitigate any potential risks.

Formula: C₄H₇NO₅

InChI: InChI=1/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/s2

InChI key: InChIKey=YYLQUHNPNCGKJQ-FNNSSLBKNA-N

SMILES: [C@H]([C@@H](C(O)=O)O)(C(O)=O)N

Synonyms:

• (3R)-2-amino-3-hydroxy-butanedioic acid
• <span class="text-smallcaps">D</span>-Aspartic acid, 3-hydroxy-, (3R)-rel-
• <span class="text-smallcaps">DL</span>-Aspartic acid, 3-hydroxy-, threo-
• <span class="text-smallcaps">DL</span>-threo-3-Hydroxyaspartic acid
• <span class="text-smallcaps">DL</span>-threo-β-Hydroxyaspartic acid
• Aspartic acid, 3-hydroxy-, <span class="text-smallcaps">DL</span>-threo-
• DL-threo--Hydroxyaspartic Acid
• rel-(3R)-3-Hydroxy-<span class="text-smallcaps">D</span>-aspartic acid
• threo-3-Hydroxy-<span class="text-smallcaps">DL</span>-aspartic acid
• DL-threo-3-Hydroxyaspartic acid
• rel-(3R)-3-Hydroxy-D-aspartic acid
• Aspartic acid, 3-hydroxy-, DL-threo-
• D-Aspartic acid, 3-hydroxy-, (3R)-rel-

DL-Threo-β-Hydroxyaspartic acid

CAS: 4294-45-5

Formula: C₄H₇NO₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 149.1021

Ref: IN-DA00BZLF

D,L-threo-β-Hydroxy aspartic acid

CAS: 4294-45-5

Formula: C₄H₇NO₅

Molecular weight: 149.10

Ref: 7W-GM7475

D,L-threo-β-Hydroxy Aspartic Acid

CAS: 4294-45-5

Formula: C₄H₇NO₅

Color and Shape: Neat

Molecular weight: 149.10

Ref: TR-H828525

D,L-Threo-b-hydroxy aspartic acid

CAS: 4294-45-5

D,L-Threo-b-hydroxy aspartic acid is a stereoselective synthetic amino acid that has been used to study the uptake and hydrolysis of D,L-threo-b-hydroxy aspartic acid by rat brain synaptosomes. It has also been used in the synthesis of an L-alanine analogue with the same stereochemistry at the chiral center. The stereoselective synthesis of this compound is achieved by epimerization reaction using d-alanine as a starting material. Threo bhda has been shown to inhibit glutamate release from neurons and stimulate GABA release in synaptosomes, which may be due to its ability to bind to ion channels. Threo bhda has also been found to inhibit the binding of radioactive thymidine to calf thymus DNA with a high degree of stereoselectivity.

Formula: C₄H₇NO₅

Purity: Min. 95%

Molecular weight: 149.1 g/mol

Ref: 3D-FT28259