CAS 42959-38-6

2-Chloro-5-nitronicotinic acid

Description:

2-Chloro-5-nitronicotinic acid is a chemical compound that belongs to the class of heterocyclic aromatic compounds, specifically a derivative of nicotinic acid. It features a pyridine ring with a chlorine atom and a nitro group attached at the 2 and 5 positions, respectively. This compound is characterized by its polar nature due to the presence of both the carboxylic acid and nitro functional groups, which can influence its solubility in various solvents. The chlorine substituent can also affect its reactivity and biological activity. 2-Chloro-5-nitronicotinic acid may exhibit interesting pharmacological properties, making it a subject of interest in medicinal chemistry. Its synthesis typically involves multi-step reactions that introduce the chlorine and nitro groups onto the nicotinic acid framework. As with many chemical substances, safety precautions should be taken when handling it, as it may pose health risks or environmental hazards. Proper storage and disposal methods are essential to mitigate any potential risks associated with this compound.

Formula: C₆H₃ClN₂O₄

InChI: InChI=1/C6H3ClN2O4/c7-5-4(6(10)11)1-3(2-8-5)9(12)13/h1-2H,(H,10,11)

SMILES: c1c(cnc(c1C(=O)O)Cl)N(=O)=O

Synonyms:

• 2-Chloro-?5-nitro-3-py?ridine?carboxyli?c acid
• 2-Chloro-5-nitropyridine-3-carboxylic acid
• 3-Pyridinecarboxylic acid, 2-chloro-5-nitro-
• 42959-38-6

2-Chloro-5-nitronicotinic acid

CAS: 42959-38-6

Formula: C₆H₃ClN₂O₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 202.5520

Ref: IN-DA0037FQ

2-Chloro-5-nitronicotinic acid

CAS: 42959-38-6

2-Chloro-5-nitronicotinic acid

Formula: C₆H₃ClN₂O₄

Purity: 95%

Color and Shape: Powder

Molecular weight: 202.55g/mol

Ref: 54-OR11941

2-Chloro-5-nitronicotinic acid

CAS: 42959-38-6

Formula: C₆H₃ClN₂O₄

Purity: ≥95%

Color and Shape: Solid

Molecular weight: 202.55

Ref: 10-F049184

2-Chloro-5-nitronicotinic acid

CAS: 42959-38-6

2-Chloro-5-nitronicotinic acid is an inhibitor of HIV-1 reverse transcriptase. It binds reversibly to the active site of the enzyme and blocks its ability to synthesize DNA, thus inhibiting HIV replication. 2-Chloro-5-nitronicotinic acid also inhibits the activity of wild type and mutant forms of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase with high potency. This drug has been shown to be effective against nevirapine resistant HIV strains. The molecular modeling studies suggest that 2-chloro-5 nitronicotinic acid binds to a hydrophobic pocket in the active site of HIV reverse transcriptase, which is different from other inhibitors such as AZT, ddI, and ddC.

Formula: C₆H₃ClN₂O₄

Purity: Min. 95%

Molecular weight: 202.55 g/mol

Ref: 3D-SBA95938