CAS 43188-86-9

hydrocortisone 3-O-carboxymethyloxime

Description:

Hydrocortisone 3-O-carboxymethyloxime, with the CAS number 43188-86-9, is a derivative of hydrocortisone, a steroid hormone produced by the adrenal glands. This compound features a carboxymethyloxime functional group at the 3-position of the hydrocortisone structure, which modifies its chemical properties and biological activity. It is typically characterized by its molecular formula, which reflects the presence of carbon, hydrogen, nitrogen, and oxygen atoms. The introduction of the oxime group can influence the compound's solubility, stability, and reactivity, potentially enhancing its pharmacological effects. Hydrocortisone derivatives are often studied for their anti-inflammatory and immunosuppressive properties, making them relevant in therapeutic applications. The specific characteristics, such as melting point, solubility, and spectral data, would depend on the compound's purity and the conditions under which it is analyzed. Overall, hydrocortisone 3-O-carboxymethyloxime represents a modification of a well-known steroid, with potential implications in medicinal chemistry and pharmacology.

Formula: C₂₃H₃₃NO₇

InChI: InChI=1/C23H33NO7/c1-21-7-5-14(24-31-12-19(28)29)9-13(21)3-4-15-16-6-8-23(30,18(27)11-25)22(16,2)10-17(26)20(15)21/h9,15-17,20,25-26,30H,3-8,10-12H2,1-2H3,(H,28,29)/b24-14+/t15-,16-,17-,20?,21-,22-,23-/m0/s1

Synonyms:

• 4-PREGNEN-11-BETA, 17,21-TRIOL-3,20-DIONE 3-O-CARBOXYMETHYLOXIME
• HYDROCORTISONE 3-(O-CARBOXYMETHYL)OXIME
• CORTISOL 3-CMO
• 4-PREGNENE-11BETA,17ALPHA,21-TRIOL-3,20-DIONE 3-[O-CARBOXYMETHYL]OXIME
• Cortisol 3-Carboxymethyloxime
• 4-Pregnene-11β,17α,21-Triol-3,20-Dione 3-(O-Carboxymethyl)Oxime
• 11β,17α,21-trihydroxy-4-pregnene-3,20-dione 3-(o-carboxymethyl)oxime
• 11BETA,17ALPHA,21-TRIHYDROXY-4-PREGNENE-3,20-DIONE 3-[O-CARBOXYMETHYL]OXIME
• Hydrocortisone Impurity 56
• Acetic acid, 2-[[[(11β)-11,17,21-trihydroxy-20-oxopregn-4-en-3-ylidene]amino]oxy]-
• Cortisol 3-(O-carboxymethyl)oxime, 4-Pregnene-11β,17α,21-triol-3,20-dione 3-(O-carboxymethyl)oxime, 11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 3-(O-carboxymethyl)oxime
• CORTISOL 3-[O-CARBOXYMETHYL]OXIME
• HYDROCORTISONE 3-CMO
• Hydrocortisone 3-(O-Carboxymethyl)oxime (E/Z Mixture)
• 4-PREGNEN-11β, 17, 21-TRIOL-3, 20-DIONE 3-O-CARBOXYMETHYLOXIME

Hydrocortisone 3-(O-carboxymethyl)oxime

CAS: 43188-86-9

Formula: C₂₃H₃₃NO₇

Molecular weight: 435.51

Ref: 7W-GL3591

Hydrocortisone 3-(O-carboxymethyl)oxime

Controlled Product

CAS: 43188-86-9

Hydrocortisone 3-(O-carboxymethyl)oxime is a water-soluble compound that has shown potential in the treatment of lung cancer. It has been found to enhance the uptake of d-allulose, a sugar substitute, which can help regulate blood sugar levels. Additionally, hydrocortisone 3-(O-carboxymethyl)oxime has been incorporated into nanocomposites for photocatalytic applications, specifically in the degradation of cancer-causing substances in water. This compound has also demonstrated controlled release properties when used as an electrode coating, allowing for targeted delivery of therapeutic agents. In studies conducted on human cells, hydrocortisone 3-(O-carboxymethyl)oxime showed promising results in inhibiting the growth of lung cancer cells and reducing tumor size. Further research is underway to explore its potential as a novel anticancer therapy.

Formula: C₂₃H₃₃NO₇

Molecular weight: 435.52 g/mol

Ref: 3D-J-022769

Cortisol 3-CMO

CAS: 43188-86-9

Cortisol 3-CMO is a highly effective antibody-drug conjugate that targets choroidal neovascularization, a condition characterized by the abnormal growth of blood vessels in the choroid layer of the eye. It works by binding to specific growth factors involved in this process and delivering a cytotoxic toxin subunit to the targeted cells. This leads to the lysis and elimination of these cells, effectively treating the condition. The unique feature of Cortisol 3-CMO is its fluorophore component, which allows for easy visualization and tracking of the drug within the body. This enables healthcare professionals to monitor its distribution and efficacy during treatment. In addition to its therapeutic benefits, Cortisol 3-CMO also exhibits excellent photostability, ensuring its potency even under prolonged exposure to light. This makes it a reliable and long-lasting solution for patients suffering from choroidal neovascularization. Developed using advanced monoclonal antibody technology, Cortisol 3-CMO offers high specificity and

Formula: C₂₃H₃₃NO₇

Purity: Min. 95%

Molecular weight: 435.51 g/mol

Ref: 3D-80-IC15

Hydrocortisone 3-(O-carboxymethyl)oxime

Controlled Product

CAS: 43188-86-9

Hydrocortisone 3-(O-carboxymethyl)oxime is a fine chemical that is used as a building block in research and speciality chemicals. It has been shown to be a useful intermediate for the synthesis of other compounds, such as corticosteroids, and could be used as a scaffold for the synthesis of natural products. Hydrocortisone 3-(O-carboxymethyl)oxime is an ester that is derived from hydrocortisone by reacting it with oxalyl chloride and methanol. This product has CAS No. 43188-86-9, indicating that it is a high quality product.

Formula: C₂₃H₃₃NO₇

Purity: Min. 95%

Molecular weight: 435.5 g/mol

Ref: 3D-FH181853

Hydrocortisone 3-(O-Carboxymethyl)oxime (E/Z Mixture)

Controlled Product

CAS: 43188-86-9

Applications Hydrocortisone 3-(O-Carboxymethyl)oxime is a model steroid that was coupled with bovine serum albumin (F-3-O-CMO-BSA) and used as immunogen to raise the antiserum in New Zealand white rabbits.It is derived from Hydrocortisone (H714615), which is a topical corticosteroid (1), more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland (2). Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis (3); suppress the immune system; and aid in fat, protein and carbohydrate metabolism.
References Nara, S., et al.: Anal. Biochem., 373, 18-25 (2008)

Formula: C₂₃H₃₃NO₇

Color and Shape: Neat

Molecular weight: 435.511

Ref: TR-H716568