CAS 43200-80-2

Zopiclone

Description:

Zopiclone is a non-benzodiazepine hypnotic agent primarily used for the treatment of insomnia. It belongs to the cyclopyrrolone class of compounds and is characterized by its sedative and anxiolytic properties. The chemical formula of Zopiclone is C17H17ClN6O3, and it features a unique structure that includes a pyrrolone ring, which contributes to its pharmacological effects. Zopiclone acts on the central nervous system by enhancing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that promotes sleep and relaxation. It is typically administered in tablet form and is known for its rapid onset of action, making it effective for short-term management of sleep disorders. Common side effects may include drowsiness, dizziness, and potential dependence with prolonged use. Due to its sedative effects, caution is advised when operating machinery or driving after taking Zopiclone. As with any medication, it is important to use Zopiclone under the guidance of a healthcare professional to mitigate risks and ensure safe usage.

Formula: C₁₇H₁₇ClN₆O₃

InChI: InChI=1S/C17H17ClN6O3/c1-22-6-8-23(9-7-22)17(26)27-16-14-13(19-4-5-20-14)15(25)24(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3

InChI key: InChIKey=GBBSUAFBMRNDJC-UHFFFAOYSA-N

SMILES: O(C(=O)N1CCN(C)CC1)C2N(C(=O)C=3C2=NC=CN3)C4=CC=C(Cl)C=N4

Synonyms:

• (.+-.)-Zopiclone
• 5H-Pyrrolo[3,4-b]pyrazine, 1-piperazinecarboxylic acid deriv.
• Amoban
• Amovane
• Hypnor
• Imoclone
• Imovance
• Imovane
• Rp 27267
• Sopivan
• Zimovane
• Zopiclon
• Zopiclona
• 1-Piperazinecarboxylic acid, 4-methyl-, 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl ester
• 4-({[(5R)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl]oxy}carbonyl)-1-methylpiperazin-1-ium
• 4-({[(5S)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl]oxy}carbonyl)-1-methylpiperazin-1-ium
• 4-Methyl-1-piperazinecarboxylic acid 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl ester
• 27267r.p.
• 27267 R.P.
• 4-methyl-,6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-1-piperazinecarboxylicaci
• 4-Methyl-1-piperazinecarboxylic acid ester with 6-(5-chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one
• Zopicclone
• 6-(5-Chloro-2-pyridinyl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methyl-1-piperazinecarboxylate
• 4-Methyl-1-piperazine-carboxylic Acid 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl Ester
• 4-METHYLPIPERAZINE-1-CARBOXYLIC ACID 6-(5-CHLORO-PYRIDIN-2-YL)-7-OXO-6,7-DIHYDRO-5H-PYRROLO[3,4-B]PY

Zopiclone 1.0 mg/ml in Acetonitrile

CAS: 43200-80-2

Color and Shape: Single Solution

Ref: 61-AMP0149.00-11

Zopiclone

CAS: 43200-80-2

Color and Shape: Neat

Ref: 61-FOR0149.00

Zopiclone, 1mg/ml in Acetonitrile

CAS: 43200-80-2

Color and Shape: Single Solution

Ref: LP-ZOP-921-FB-1LA

Zopiclone

Controlled Product

CAS: 43200-80-2

Color and Shape: Neat

Ref: LP-ZOP-921-FB-10

Zopiclone

CAS: 43200-80-2

Formula: C₁₇H₁₇ClN₆O₃

Molecular weight: 388.81

Ref: 4Z-Z-0637

Zopiclone

CAS: 43200-80-2

Formula: C₁₇H₁₇ClN₆O₃

Molecular weight: 388.81

Ref: 7W-GP1081

(±)-Zopiclone-d3 (N-methyl-d3)

Controlled Product

CAS: 1398066-10-8, 43200-80-2

Purity: 99 atom % D

Color and Shape: White Solid

Molecular weight: 391.83

Ref: 3U-D7385

Zopiclone

CAS: 43200-80-2

Color and Shape: White To Off-White

Ref: 86-MM0149.00

Zopiclone

Controlled Product

CAS: 43200-80-2

Formula: C₁₇H₁₇ClN₆O₃

Color and Shape: Neat

Molecular weight: 388.81

Ref: 04-C17978000

Zopiclone-d4

CAS: 43200-80-2

Formula: C₁₇H₁₃D₄ClN₆O₃

Molecular weight: 392.84

Ref: 4Z-Z-0615

Zopiclone

Controlled Product

CAS: 43200-80-2

Stability Hygroscopic
Applications Cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists. This is a controlled substance (depressant) in the US but not in Canada. Sedative, hypnotic.
References Noble, S., et al.: Drugs, 55, 277 (1998), Musch, B., et al.: Int. J. Clin. Psychopharmacol., 5, 147 (1990),

Formula: C₁₇H₁₇ClN₆O₃

Color and Shape: White To Off-White

Molecular weight: 388.81

Ref: TR-Z700500

Zopiclone

Controlled Product

CAS: 43200-80-2

Zopiclone is a benzodiazepine that has been shown to have potent inducers of hepatic enzymes. It is used for the treatment of insomnia, but long-term use may lead to tolerance and dependence. Zopiclone binds to the receptor site for GABA, which is a neurotransmitter. It also affects other neurotransmitters such as monoamines, which are involved in mood control and arousal. Zopiclone has been shown to be beneficial in patients with congestive heart failure, although it can cause orthostatic hypotension. The matrix effect of zopiclone is significant, leading to drug interactions with other drugs taken at the same time. Zopiclone has been shown to be effective in treating chronic insomnia and its long-term efficacy appears to be good.

Formula: C₁₇H₁₇ClN₆O₃

Molecular weight: 388.81 g/mol

Ref: 3D-W-106239

Zopiclone

Controlled Product

CAS: 43200-80-2

Antagonist of GABA(A); hypnotic agent

Formula: C₁₇H₁₇ClN₆O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 388.81 g/mol

Ref: 3D-FZ156793

ZOPICLONE CRS - * PSY

Controlled Product

CAS: 43200-80-2

ZOPICLONE CRS - * PSY

Formula: C₁₇H₁₇ClN₆O₃

Color and Shape: Powder

Molecular weight: 388.8083

Ref: 41-Z3000000

Zopiclone

Controlled Product

CAS: 43200-80-2

Zopiclone

Formula: C₁₇H₁₇CIN₆O₃

Purity: 99.8%

Color and Shape: White To Off-White

Molecular weight: 492.04069

Ref: 47-812

Zopiclone (1 mg/mL in Acetonitrile)

Controlled Product

CAS: 43200-80-2

Formula: C₁₇H₁₇ClN₆O₃

Color and Shape: Colourless

Molecular weight: 388.81

Ref: TR-KIT0130