CAS 43200-96-0

Zopiclone N-oxide

Description:

Zopiclone N-oxide is a chemical compound derived from zopiclone, a medication primarily used for the treatment of insomnia. As an N-oxide derivative, it features an oxygen atom bonded to a nitrogen atom, which alters its pharmacological properties compared to its parent compound. Zopiclone N-oxide is characterized by its molecular structure, which includes a bicyclic framework typical of many sedative-hypnotics. This compound is generally recognized for its sedative effects, although it may exhibit different potency and efficacy compared to zopiclone itself. The presence of the N-oxide functional group can influence its solubility, stability, and interaction with biological targets, potentially affecting its metabolism and pharmacokinetics. While zopiclone is known for its ability to enhance GABAergic activity in the central nervous system, the specific mechanisms and effects of Zopiclone N-oxide may require further investigation to fully understand its therapeutic potential and safety profile. As with any pharmaceutical compound, appropriate handling and usage guidelines should be followed to ensure safety and efficacy.

Formula: C₁₇H₁₇ClN₆O₄

InChI: InChI=1S/C17H17ClN6O4/c1-24(27)8-6-22(7-9-24)17(26)28-16-14-13(19-4-5-20-14)15(25)23(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3

InChI key: InChIKey=IPTIKKTXLHVRKN-UHFFFAOYSA-N

SMILES: O(C(=O)N1CCN(C)(=O)CC1)C2N(C(=O)C=3C2=NC=CN3)C4=CC=C(Cl)C=N4

Synonyms:

• 1-Piperazinecarboxylic acid, 4-methyl-, 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl ester, 4-oxide
• 5H-Pyrrolo[3,4-b]pyrazine, 1-piperazinecarboxylic acid deriv.
• 6-(5-Chloro-2-pyridyl)-7-((4-oxo-4-methyl-1-piperazinyl)carbonyloxy)-6,7-dihydro(5H)pyrrolo(3,4-b)pyrazin-5-one
• Rp 29753
• Zopiclone N-oxide

Zopiclone Oxide 1.0 mg/ml in Dimethyl Sulfoxide

CAS: 43200-96-0

Color and Shape: Colourless

Ref: 61-AMP0149.01-29

Zopiclone Oxide

CAS: 43200-96-0

Color and Shape: White To Light Brown

Ref: 61-FOR0149.01

Eszopiclone Related Compound A (6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo [3,4,b] pyrazin-5-yl 4-methylpiperazine-1-carboxylate 4-oxide)

CAS: 43200-96-0

Lactams not elsewhere specified or included

Formula: C₁₇H₁₇ClN₆O₄

Color and Shape: Off-White Powder

Molecular weight: 404.09998

Ref: 45-1255861

Zopiclone EP Impurity A (Eszopiclone USP Related Compound A, Zopiclone N-Oxide)

CAS: 43200-96-0

Formula: C₁₇H₁₇ClN₆O₄

Color and Shape: Off-White Solid

Molecular weight: 404.82

Ref: 4Z-Z-068

(5RS)-6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-Methylpiperazine-1-carboxylate 4-Oxide (Zopiclone Oxide)

Controlled Product

CAS: 43200-96-0

Formula: C₁₇H₁₇ClN₆O₄

Color and Shape: Neat

Molecular weight: 404.81

Ref: 86-MM0149.01

Zopiclone EP Impurity A

CAS: 43200-96-0

Formula: C₁₇H₁₇ClN₆O₄

Molecular weight: 404.81

Ref: ST-EA-CP-Z2008

Zopiclone N-Oxide

CAS: 43200-96-0

Impurity Zopiclone EP Impurity A
Applications Eszopiclone impurity A.
References Vire, J.C., et al.: Talanta, 40, 313 (1993), Sha, Yu., et al.: Molecules, 13, 1817 (2008),

Formula: C₁₇H₁₇ClN₆O₄

Color and Shape: White To Light Brown

Molecular weight: 404.81

Ref: TR-Z700510

Zopiclone N-oxide

Controlled Product

CAS: 43200-96-0

Zopiclone N-oxide is a metabolite of zopiclone, an anxiolytic drug. This compound is formed by the oxidation of zopiclone and has been detected in human liver. Zopiclone N-oxide has a short half-life and elimination rate, which may be due to the stereoselective metabolism of this compound. Zopiclone N-oxide has been shown to have a greater effect on the central nervous system than zopiclone, but does not induce drug interactions or affect urine samples. The detection time for this compound is shorter than for zopiclone, which may be due to its higher concentration in the blood.

Formula: C₁₇H₁₇ClN₆O₄

Purity: Min. 95%

Molecular weight: 404.81 g/mol

Ref: 3D-IZ28786