CAS 43218-56-0

Midodrine hydrochloride

Description:

Midodrine hydrochloride is a synthetic medication primarily used as a vasopressor to treat orthostatic hypotension, a condition characterized by abnormally low blood pressure upon standing. It acts as an alpha-1 adrenergic agonist, leading to vasoconstriction and an increase in blood pressure. The chemical formula for midodrine hydrochloride is C12H17ClN2O4S, and it is typically administered in its hydrochloride salt form to enhance solubility and stability. This compound is characterized by its white to off-white crystalline powder appearance and is soluble in water and alcohol. Midodrine is metabolized in the liver to its active metabolite, desglymidodrine, which also contributes to its pharmacological effects. Common side effects may include piloerection, urinary retention, and hypertension, particularly if doses are not carefully managed. Due to its mechanism of action, midodrine is contraindicated in patients with certain cardiovascular conditions, and its use requires careful monitoring of blood pressure levels.

Formula: C₁₂H₁₈N₂O₄·ClH

InChI: InChI=1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H

InChI key: InChIKey=MGCQZNBCJBRZDT-UHFFFAOYSA-N

SMILES: C(CNC(CN)=O)(O)C1=C(OC)C=CC(OC)=C1.Cl

Synonyms:

• ( -)-Midodrin hydrochloride
• ( -)-Midodrine hydrochloride
• 1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol hydrochloride
• 2-Amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)acetamide hydrochloride
• 2-Amino-N-(2-(2,5-dimethoxyphenyl)-2-hyyroxyethyl)acetamide monohydrochloride
• A 4020 Linz
• Acetamide, 2-amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)-, monohydrochloride
• Acetamide, 2-amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)-, hydrochloride
• Acetamide, 2-amino-N-(β-hydroxy-2,5-dimethoxyphenethyl)-, hydrochloride
• Acetamide, 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-, hydrochloride (1:1)
• Alphamine
• Amatine
• Gutron
• Hipertan
• Metligene
• Midamine
• Midodrine HCl
• Midodrine hydrochloride [USAN]
• ProAmatine
• St 1085
• St. Peter 224
• Ts 701
• Unii-59Jv96Ytxv
• 2-Amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)acetamide monohydrochloride
• Natildine
• Acetamide, 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-, monohydrochloride (9CI)
• Abalnate
• Shuprase

2-Amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)acetamide hydrochloride

CAS: 43218-56-0

Formula: C₁₂H₁₉ClN₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 290.7433

Ref: IN-DA0031NM

Midodrine HCl

CAS: 43218-56-0

Formula: C₁₂H₁₈N₂O₄·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 254.29 36.46

Ref: 4Z-M-115

Mexiletine Impurity 2

CAS: 43218-56-0

Formula: C₁₈H₂₂O₄S

Color and Shape: White To Off-White Solid

Molecular weight: 334.43

Ref: 4Z-M-115009

Midodrine hydrochloride

CAS: 43218-56-0

Formula: C₁₂H₁₉ClN₂O₄

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 290.74

Ref: 7W-GP7563

Midodrine hydrochloride

Controlled Product

CAS: 43218-56-0

Midodrine hydrochloride is a nonsteroidal anti-inflammatory drug that belongs to the group of pharmacological agents. It is indicated for the treatment of congestive heart failure, and works by increasing the blood pressure in both systemic and pulmonary circulations. This drug has been shown to be effective in reducing left ventricular end diastolic volume, which may improve cardiac function. The mechanism of action of midodrine hydrochloride is not fully understood but it likely affects energy metabolism and blood flow through vascular smooth muscle cells. Midodrine hydrochloride has been shown to have no significant effects on metabolic disorders or analytical methods.

Formula: C₁₂H₁₈N₂O₄•HCl

Purity: Min. 95%

Color and Shape: White/Off-White Solid

Molecular weight: 290.74 g/mol

Ref: 3D-FM26001

Midodrine Hydrochloride

Controlled Product

CAS: 43218-56-0

Applications A phenylalkanolamine derivative which has been found to be effective in treating hypertensive conditions due to their long lasting blood pressure increasing effects.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),

Formula: C₁₂H₁₈N₂O₄·ClH

Color and Shape: White To Off-White

Molecular weight: 290.74

Ref: TR-M343750