CAS 43229-80-7

Formoterol fumarate

Description:

Formoterol fumarate is a long-acting beta-2 adrenergic agonist primarily used in the management of asthma and chronic obstructive pulmonary disease (COPD). It is characterized by its ability to relax bronchial smooth muscle, leading to bronchodilation and improved airflow. The substance is a white to off-white crystalline powder, soluble in water and methanol, and has a molecular formula that reflects its complex structure, which includes a fumarate salt form. Formoterol fumarate exhibits a rapid onset of action, typically within minutes, and provides prolonged therapeutic effects, lasting up to 12 hours or more. It is often administered via inhalation, either as a dry powder or aerosol, allowing for targeted delivery to the lungs. Additionally, it may be combined with corticosteroids to enhance anti-inflammatory effects. As with any medication, potential side effects can include tremors, palpitations, and headache, necessitating careful monitoring in patients with cardiovascular conditions. Overall, Formoterol fumarate plays a crucial role in respiratory therapy, offering significant benefits for individuals with obstructive airway diseases.

Formula: C₁₉H₂₄N₂O₄C₄H₄O₄

InChI: InChI=1/C19H24N2O4.C4H4O4/c1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22;5-3(6)1-2-4(7)8/h3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22);1-2H,(H,5,6)(H,7,8)/b;2-1+/t13-,19+;/s2

InChI key: InChIKey=ZDUPYZMAPCZGJO-MAKVIOGJNA-N

SMILES: [C@H](CN[C@H](CC1=CC=C(OC)C=C1)C)(O)C2=CC(NC=O)=C(O)C=C2.C(=C/C(O)=O)\C(O)=O

Synonyms:

• (+-)-2'-Hydroxy-5'-((R*)-1-hydroxy-2-(((R*)-p-methoxy-alpha-methylphenethyl)amino)ethyl)formanilide fumarate (2:1) (salt)
• Aformoterol
• Atock
• Bd 40A
• Cgp 25827A
• Eformoterol fumarate
• Foradil
• Foradil Aerolizer
• Foradil Certihaler
• Foradil acrolizer
• Formamide, N-(2-hydroxy-5-((1R)-1-hydroxy-2-(((1R)-2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)phenyl)-, rel-, (E)-2-butenedioate (2:1) (salt)
• Formamide, N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, rel-, (2E)-2-butenedioate (2:1) (salt)
• Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, (R*,R*)-(±)-, (E)-2-butenedioate (2:1) (salt)
• N-(2-Hydroxy-5-(1-hydroxy-2-((2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)phenyl)formamide, (E)-2-butenedioate (2:1) (salt)
• N-[2-hydroxy-5-(1-hydroxy-2-{[2-(4-methoxyphenyl)-1-methylethyl]amino}ethyl)phenyl]formamide (2E)-but-2-enedioate (salt)
• N-{2-hydroxy-5-[(1R)-1-hydroxy-2-{[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino}ethyl]phenyl}formamide (2E)-but-2-enedioate (salt)
• N-{2-hydroxy-5-[(1S)-1-hydroxy-2-{[(1S)-2-(4-methoxyphenyl)-1-methylethyl]amino}ethyl]phenyl}formamide
• N-{2-hydroxy-5-[(1S)-1-hydroxy-2-{[(1S)-2-(4-methoxyphenyl)-1-methylethyl]amino}ethyl]phenyl}formamide (2E)-but-2-enedioate (salt)
• Nsc 299587
• Oxis pMDi
• Perforomist
• Unii-P3T5Qa5J9N
• Ym-08316

Formoterol Fumarate

CAS: 43229-80-7

Formula: C₁₉H₂₄N₂O₄C₄H₄O₄

Purity: min. 97.0 % (total of 2peaks)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 402.45

Ref: 3B-F0881

FORMOTEROL FOR IMPURITY I IDENTIFICATION CRS

CAS: 43229-80-7

FORMOTEROL FOR IMPURITY I IDENTIFICATION CRS

Formula: C₁₉H₂₄N₂O₄

Color and Shape: White. Light Yellow. Powder.

Molecular weight: 344.4049

Ref: 41-Y0000339

FORMOTEROL FOR SYSTEM SUITABILITY CRS

CAS: 43229-80-7

FORMOTEROL FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0002298

Formoterol-13C-d3 Hemifumarate

CAS: 43229-80-7

Formula: C₁₈₁₃CH₂₁D₃N₂O₄·5C₄H₄O₄

Color and Shape: White To Off-White Solid

Molecular weight: 348.42 0.5*116.07

Ref: 4Z-F-112

Formoterol fumarate

CAS: 43229-80-7

Formula: C₂₃H₂₈N₂O₈

Purity: ≥ 98.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 460.48

Ref: 7W-GP2103

Formoterol Hemifumarate

CAS: 43229-80-7

Formula: C₁₉H₂₄N₂O₄·5C₄H₄O₄

Color and Shape: White To Off-White Solid

Molecular weight: 344.41 0.5*116.07

Ref: 4Z-F-113

Eformoterol Hemifumarate

CAS: 43229-80-7

Formoterol fumarate (Eformoterol Hemifumarate), an effective, specific and long-acting β2-adrenoceptor agonist, is utilized in the treatment of COPD and asthma

Formula: C₁₉H₂₄N₂O₄C₄H₄O₄

Purity: 99.86% - >99.99%

Color and Shape: White Powder

Molecular weight: 402.4

Ref: TM-T6505

Formoterol-d6 Fumarate

Controlled Product

CAS: 43229-80-7

Stability Hygroscopic
Applications Formoterol-d6 Fumarate is the labeled analogue of Formoterol Fumarate (F693401), an impurity of Formoterol fumarate dihydrate (F693400), a selective β2-adrenergic receptor agonist. Formoterol is used as an antiasthmatic.
References Yoshida, T., et al.: Pharmacometrics, 26, 811 (1983); Bartow, R.A., et al.: Drugs, 55, 303 (1998)

Formula: C₄₂H₄₀D₁₂N₄O₁₂

Color and Shape: Neat

Molecular weight: 816.96

Ref: TR-F693403