CAS 433-06-7

2,2,2-Trifluoroethyl p-toluenesulfonate

Description:

2,2,2-Trifluoroethyl p-toluenesulfonate, with the CAS number 433-06-7, is an organic compound characterized by the presence of a trifluoroethyl group and a p-toluenesulfonate moiety. It is typically a colorless to pale yellow liquid that is soluble in organic solvents but has limited solubility in water due to its hydrophobic characteristics. The trifluoroethyl group imparts unique properties, such as increased lipophilicity and thermal stability, making it useful in various chemical reactions, particularly in nucleophilic substitution processes. The p-toluenesulfonate part of the molecule serves as a good leaving group, enhancing its reactivity in organic synthesis. This compound is often utilized in the preparation of fluorinated compounds and can act as an electrophile in reactions with nucleophiles. Safety considerations include handling it with care due to its potential irritant properties and the environmental impact of fluorinated compounds. Overall, 2,2,2-Trifluoroethyl p-toluenesulfonate is a valuable reagent in synthetic organic chemistry.

Formula: C₉H₉F₃O₃S

InChI: InChI=1S/C9H9F3O3S/c1-7-2-4-8(5-3-7)16(13,14)15-6-9(10,11)12/h2-5H,6H2,1H3

InChI key: InChIKey=IGKCQDUYZULGBM-UHFFFAOYSA-N

SMILES: S(OCC(F)(F)F)(=O)(=O)C1=CC=C(C)C=C1

Synonyms:

• 2,2,2-Trifluoroethyl tosylate
• 2,2,2-Trifluoroethyl P-Toluenesulfonate
• Ethanol, 2,2,2-trifluoro-, 4-methylbenzenesulfonate
• Ethanol, 2,2,2-trifluoro-, p-toluenesulfonate
• Ethanol, 2,2,2-trifluoro-, 1-(4-methylbenzenesulfonate)
• 2,2,2-Trifluoroethyl p-toluenesulfonate
• TRIFLUORETHYLTOSYLATE
• 2,2,2-TRIFLUOROETHYL-4-TOLUENESULFONATE
• 2,2,2-Trifluoroethyl 4-toluenesulphonate 98%
• 2,2,2-Trifluoroethyl p-toluenesulfonate, 98+%
• p-Methylbenzenesulfonic acid 2,2,2-trifluoromethyl
• TRIFLUOROETHANOL TOSYLATE
• 2,2,2-TRIFLUOROETHYL P-TOLUENESULPHONATE
• 2,2,2-trifluoro-ethano4-methylbenzenesulfonate
• 2,2,2-TRIFLUOROETHYL 4-TOLUENESULPHONATE
• p-Toluenesulphonic acid 2,2,2-trifluoroethyl ester
• 4-Toluenesulfonic acid 2,2,2,-trifluoroethyl ester
• 4-Methylbenzenesulfonic acid 2,2,2-trifluoroethyl ester
• 2,2,2-Trifluoroethyl4-toluenesulphonate98%
• 2,2,2-TRIFLUOROETHYL 4-METHYLBENZENESULFONATE
• P-TOLUENESULFONIC ACID 2,2,2-TRIFLUOROETHYL ESTER

2,2,2-Trifluoroethyl p-Toluenesulfonate

CAS: 433-06-7

Formula: C₉H₉F₃O₃S

Purity: >98.0%(GC)(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 254.22

Ref: 3B-T1516

2,2,2-Trifluoroethyl p-toluenesulfonate, 98+%

CAS: 433-06-7

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₉H₉F₃O₃S

Purity: 98+%

Color and Shape: White to pale cream, Crystals or powder or crystalline powder

Molecular weight: 254.22

Ref: 02-A17871

2,2,2-Trifluoroethyl 4-methylbenzenesulfonate

CAS: 433-06-7

Formula: C₉H₉F₃O₃S

Purity: 97%

Color and Shape: Solid

Molecular weight: 254.2262

Ref: IN-DA003B2V

2,2,2-Trifluoroethyl toluene-4-sulphonate

CAS: 433-06-7

2,2,2-Trifluoroethyl toluene-4-sulphonate

Formula: C₉H₉F₃O₃S

Purity: 98%

Color and Shape: white crystalline powder

Molecular weight: 254.23g/mol

Ref: 54-PC7376

2,2,2-Trifluoroethyl Tosylate

Controlled Product

CAS: 433-06-7

Applications 2,2,2-Trifluoroethyl Tosylate is a trifluoroethylation agent used in the preparation of 2,2,2-trifluoroethyl phenyl sulfone, a potential 2,2,2-trifluoroethyl pronucleophile.
References Zhang, W., et. al.: Tetrahedron Lett., 53, 6565 (2012)

Formula: C₉H₉F₃O₃S

Color and Shape: Neat

Molecular weight: 254.23

Ref: TR-T790230

2,2,2-Trifluoroethyl p-toluenesulfonate

CAS: 433-06-7

Formula: C₉H₉F₃O₃S

Purity: 97%

Color and Shape: Solid, Chunks or Crystalline Powder

Molecular weight: 254.22

Ref: 10-F001538

2,2,2-Trifluoroethyl 4-methylbenzenesulfonate

CAS: 433-06-7

2,2,2-Trifluoroethyl 4-methylbenzenesulfonate (TFMBES) is a nucleophile that is used in cross-coupling reactions. It can be prepared by the reaction of butyllithium with 2,2,2-trifluoroethanol and then reacting it with methyl benzenesulfonyl chloride. TFMBES reacts with palladium dichloride to form a palladium-carbanion complex that then reacts with an organic electrophile to form the desired product. TFMBES is also used as a precursor in the preparation of trialkylboranes, which are precursors for dehydrogenation reactions.

Formula: C₉H₉F₃O₃S

Purity: Min. 95%

Molecular weight: 254.23 g/mol

Ref: 3D-FT105964