CAS 4351-48-8

(11β,16β)-9-Fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione

Description:

The chemical substance known as (11β,16β)-9-Fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione, with the CAS number 4351-48-8, is a synthetic corticosteroid. It exhibits anti-inflammatory and immunosuppressive properties, making it useful in various therapeutic applications, particularly in the treatment of conditions such as asthma, allergies, and autoimmune disorders. The structure of this compound features a fluorine atom, which enhances its potency and metabolic stability. The presence of hydroxyl and ketone functional groups contributes to its biological activity, influencing its interaction with glucocorticoid receptors. Additionally, the compound's unique steroid backbone, characterized by a pregnane structure, allows it to mimic the action of natural corticosteroids in the body. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are critical for determining its efficacy and safety profile in clinical use. Overall, this compound represents a significant advancement in corticosteroid therapy, providing targeted action with potentially reduced side effects compared to traditional steroids.

Formula: C₂₅H₃₃FO₅

InChI: InChI=1S/C25H33FO5/c1-6-21(30)31-25(15(3)27)14(2)11-19-18-8-7-16-12-17(28)9-10-22(16,4)24(18,26)20(29)13-23(19,25)5/h9-10,12,14,18-20,29H,6-8,11,13H2,1-5H3/t14-,18-,19-,20-,22-,23-,24-,25-/m0/s1

InChI key: InChIKey=ZAQGQQMIBBCIRM-RDEWRQEPSA-N

SMILES: O(C(CC)=O)[C@@]1(C(C)=O)[C@]2(C)[C@@](C[C@@H]1C)([C@]3([C@](F)([C@@H](O)C2)[C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H]

Synonyms:

• (11Beta,16Beta)-9-Fluoro-11-Hydroxy-16-Methyl-3,20-Dioxopregna-1,4-Dien-17-Yl Propanoate
• (11β,16β)-9-Fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione
• 21-Deoxybetamethasone 17-propionate
• 9-Fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11β,16β)-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17-dihydroxy-16β-methyl-, 17-propionate

Clobetasol Propionate EP Impurity H

CAS: 4351-48-8

Formula: C₂₅H₃₃FO₅

Molecular weight: 432.53

Ref: 4Z-C-101022

21-Deschloro Clobetasol 17-Propionate

CAS: 4351-48-8

Impurity Clobetasol Propionate EP Impurity H
Applications 21-Deschloro Clobetasol 17-Propionate possesses vasoconstrictor activity. Also, it is derived from Betamethasone 17-Propionate 21-Mesylate (Clobetasol Propionate EP Impurity), which is the 21-mesylate analogue of Betamethasone 17-Acetate (B327015) with anti-inflammatory activity.
References Busse, M. J., et al.: Br. J. Dermatol., 81, 103-111 (1969); Mitsukuchi, M. et al.: Chem. Pharm. Bull., 37, 3286 (1989);

Formula: C₂₅H₃₃FO₅

Color and Shape: Neat

Molecular weight: 432.52

Ref: TR-D289573

Clobetasol Propionate EP Impurity H

CAS: 4351-48-8

Formula: C₂₅H₃₃FO₅

Molecular weight: 432.53

Ref: ST-EA-CP-C81022