CAS 4366-18-1

Coumetarol

Description:

Coumetarol is a synthetic compound classified as a coumarin derivative, primarily known for its use as an anticoagulant. It exhibits properties that inhibit the synthesis of vitamin K-dependent clotting factors, thereby affecting blood coagulation. Coumetarol is characterized by its relatively low solubility in water, which influences its bioavailability and pharmacokinetics. The compound is typically administered orally and has a long half-life, allowing for once-daily dosing in therapeutic applications. Its mechanism of action involves the competitive inhibition of vitamin K epoxide reductase, an enzyme critical for the regeneration of vitamin K, which is essential for the synthesis of clotting factors II, VII, IX, and X. Coumetarol's anticoagulant effects make it useful in the prevention and treatment of thromboembolic disorders. However, like other anticoagulants, it requires careful monitoring to manage the risk of bleeding complications. Overall, Coumetarol represents an important tool in the pharmacological management of coagulation disorders, with specific characteristics that define its clinical use.

Formula: C₂₁H₁₆O₇

InChI: InChI=1/C21H16O7/c1-26-10-13(16-18(22)11-6-2-4-8-14(11)27-20(16)24)17-19(23)12-7-3-5-9-15(12)28-21(17)25/h2-9,13,24-25H,10H2,1H3

InChI key: InChIKey=BUCJFFQZPGTGPX-UHFFFAOYSA-N

SMILES: C(COC)(C1=C(O)C=2C(OC1=O)=CC=CC2)C3=C(O)C=4C(OC3=O)=CC=CC4

Synonyms:

• 1-Methoxy-2,2-bis[4-hydroxy-3-coumarinyl]ethane
• 2,2-Bis(4-hydroxy-3-coumarinyl)-1-methoxyethane
• 2H-1-Benzopyran-2-one, 3,3′-(2-methoxyethylidene)bis[4-hydroxy-
• 3,3'-(2-methoxyethane-1,1-diyl)bis(2-hydroxy-4H-chromen-4-one)
• 3,3′-(2-Methoxyethylidene)bis[4-hydroxy-2H-1-benzopyran-2-one]
• 3,3′-(2-methoxyethane-1,1-diyl)bis(4-hydroxy-2H-chromen-2-one)
• Bis-3,3′-(4-hydroxycoumarinyl)-1-(2-methoxyethane)
• Coumarin, 3,3′-(2-methoxyethylidene)bis[4-hydroxy-
• Cumetarol
• Cumetharol
• Cumethoxaethane
• Dicoumoxyl
• Dicumoxan
• Dicumoxane
• Ph 137
• Coumetarol
• Cumethoxethan
• 2-hydroxy-3-[1-(2-hydroxy-4-oxochromen-3-yl)-2-methoxyethyl]chromen-4-one
• 2-hydroxy-3-[1-(2-hydroxy-4-keto-chromen-3-yl)-2-methoxy-ethyl]chromone
• 3,3'-(2-Methoxyethylidene)bis(4-hydroxycoumarin)

Coumetarol

CAS: 4366-18-1

Coumetarol (Dicumoxane) is a vitamin K antagonist and an oral anticoagulant that can be used to study arterial thrombotic occlusion.

Formula: C₂₁H₁₆O₇

Purity: 99.01%

Color and Shape: Solid

Molecular weight: 380.35

Ref: TM-T10867

Coumetarol

Controlled Product

CAS: 4366-18-1

Formula: C₂₁H₁₆O₇

Color and Shape: Neat

Molecular weight: 380.348

Ref: TR-C781013

Coumetarol

CAS: 4366-18-1

Anti-coagulant

Formula: C₂₁H₁₆O₇

Purity: Min. 95%

Molecular weight: 380.35 g/mol

Ref: 3D-FC161379