CAS 4373-34-6

Ajmalicine hydrochloride

Description:

Ajmalicine hydrochloride, also known as serpentine, is an alkaloid derived from the plant Rauvolfia serpentina. It is characterized by its white to off-white crystalline appearance and is soluble in water and alcohol, making it suitable for various pharmaceutical applications. The compound exhibits a complex structure, featuring a tetracyclic indole alkaloid framework. Ajmalicine is primarily known for its pharmacological properties, particularly its ability to act as a vasodilator and its potential use in treating hypertension and other cardiovascular conditions. Additionally, it has been studied for its effects on the central nervous system, including sedative and anti-anxiety properties. The hydrochloride form enhances its stability and solubility, facilitating its use in medicinal formulations. As with many alkaloids, ajmalicine's activity can be influenced by its stereochemistry, and it may interact with various biological targets, including neurotransmitter receptors. Safety and efficacy profiles are essential for its therapeutic use, and ongoing research continues to explore its full potential in medicine.

Formula: C₂₁H₂₄N₂O₃·ClH

InChI: InChI=1S/C21H24N2O3.ClH/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2;/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3;1H/t12-,15-,16+,19-;/m0./s1

InChI key: InChIKey=YWPZOTNKHMBWPD-QAWKRFFXSA-N

SMILES: C(OC)(=O)C=1[C@]2(C[C@]3(C4=C(C=5C(N4)=CC=CC5)CCN3C[C@@]2([C@H](C)OC1)[H])[H])[H].Cl

Synonyms:

• 4H-Indolo[2,3-a]pyrano[3,4-g]quinolizine-1-carboxylic acid, 4a,5,7,8,13,13b,14,14a-octahydro-4-methyl-, methyl ester, hydrochloride (1:1), (4S,4aR,13bS,14aS)-
• Ajmalicine, hydrochloride
• Ajmalicine, monohydrochloride
• Ajmalicine, monohydrochloride (8CI)
• Methyl (19Alpha)-19-Methyl-16,17-Didehydro-18-Oxayohimban-16-Carboxylate Hydrochloride (1:1)
• Methyl (19alpha)-16,17-didehydro-19-methyloxayohimban-16-carboxylate hydrochloride
• Oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methyl ester, monohydrochloride
• Oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methyl ester, monohydrochloride, (19α)-
• Raubasine hydrochloride
• gamma-Yohimbin hydrochloride
• gamma-Yohimbine hydrochloride

Ajmalicine hydrochloride

CAS: 4373-34-6

Ajmalicine hydrochloride analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Formula: C₂₁H₂₄N₂O₃HCl

Purity: (HPLC) ≥95%

Color and Shape: Powder

Molecular weight: 388.9

Ref: 11-0622

Ajmalicine hydrochloride

CAS: 4373-34-6

Ajmalicine hydrochloride is a potent α1-adrenoceptor blocker, non-competitive nicotine receptor inhibitor, anti-hypertensive, and sedative. IC50: 72.3 μM.

Formula: C₂₁H₂₅ClN₂O₃

Color and Shape: Solid

Molecular weight: 388.89

Ref: TM-T69254