CAS 437715-62-3
:Guanosine,8-chloro-2'-deoxy- (9CI)
Description:
Guanosine, 8-chloro-2'-deoxy- (9CI), with the CAS number 437715-62-3, is a modified nucleoside that features a chlorine atom at the 8-position of the guanine base. This compound is a derivative of deoxyguanosine, which is one of the building blocks of DNA. The presence of the chlorine atom can influence the compound's biological activity, potentially affecting its interaction with nucleic acids and enzymes. Guanosine derivatives are often studied for their roles in cellular processes, including signal transduction and as potential therapeutic agents. The modification at the 8-position may enhance or alter the compound's properties, such as its stability, solubility, and affinity for nucleic acid targets. In research, such modified nucleosides are valuable for understanding nucleic acid structure and function, as well as for developing antiviral or anticancer drugs. As with many nucleoside analogs, the pharmacological profile and toxicity of guanosine, 8-chloro-2'-deoxy- would be of significant interest in medicinal chemistry.
Formula:C10H12ClN5O4
Synonyms:- 8-Chloro-2’-deoxy-D-guanosine
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Found 2 products.
8-Chloro-2'-deoxyguanosine
CAS:<p>8-Chloro-2'-deoxyguanosine is a reactive oxygen species that can cause oxidative damage to DNA. This compound is generated by the hypochlorous acid (HOCl) in cells and can be found in human tissues. 8-Chloro-2'-deoxyguanosine can also be generated by the HOCl in diabetic patients, where it has been shown to cause oxidative damage to DNA. 8-Chloro-2'-deoxyguanosine is a product of the reaction between hydrogen peroxide and catalase, and it is activated by HOCl. It has been shown to be carcinogenic in animal models, where it causes DNA damage that leads to cancer.</p>Formula:C10H12ClN5O4Purity:Min. 95%Color and Shape:PowderMolecular weight:301.69 g/mol
