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CAS 437742-34-2

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(-)-Salinosporamide A

Description:
(-)-Salinosporamide A, with the CAS number 437742-34-2, is a natural product derived from the marine actinomycete Salinispora tropica. This compound is notable for its potent proteasome-inhibiting activity, which has garnered interest in cancer research due to its potential therapeutic applications. Chemically, it is characterized by a bicyclic structure that includes a lactam ring, contributing to its biological activity. The compound exhibits selective cytotoxicity against various cancer cell lines, making it a candidate for further development in oncology. Additionally, (-)-Salinosporamide A has been studied for its ability to induce apoptosis in cancer cells and modulate various signaling pathways. Its unique structure and mechanism of action differentiate it from other proteasome inhibitors, such as bortezomib, highlighting its potential as a novel therapeutic agent. However, further research is necessary to fully understand its pharmacokinetics, toxicity, and efficacy in clinical settings.
Formula:C15H20ClNO4
InChI:InChI=1S/C15H20ClNO4/c1-14-10(7-8-16)12(19)17-15(14,13(20)21-14)11(18)9-5-3-2-4-6-9/h3,5,9-11,18H,2,4,6-8H2,1H3,(H,17,19)/t9-,10+,11+,14+,15+/m1/s1
InChI key:InChIKey=NGWSFRIPKNWYAO-SHTIJGAHSA-N
SMILES:[C@@H](O)([C@]12[C@](C)([C@@H](CCCl)C(=O)N1)OC2=O)[C@]3(CCCC=C3)[H]
Synonyms:
  • (1R,4R,5S)-4-(2-Chloroethyl)-1-[(S)-(1S)-2-cyclohexen-1-ylhydroxymethyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
  • (-)-Salinosporamide A
  • Salinosporamide A
  • NPI 0052
  • 6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione, 4-(2-chloroethyl)-1-[(S)-(1S)-2-cyclohexen-1-ylhydroxymethyl]-5-methyl-, (1R,4R,5S)-
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