CAS 438-07-3

16α-Hydroxyprogesterone

Description:

16α-Hydroxyprogesterone is a steroid hormone and a derivative of progesterone, characterized by the presence of a hydroxyl group at the 16α position. It is a white to off-white crystalline powder that is soluble in organic solvents but has limited solubility in water. This compound is primarily involved in the regulation of reproductive processes and is used in various medical applications, particularly in hormone replacement therapy and in the treatment of certain reproductive disorders. Its chemical structure allows it to interact with progesterone receptors, influencing gene expression and cellular activity related to pregnancy and menstrual cycle regulation. Additionally, 16α-Hydroxyprogesterone can be synthesized from progesterone through hydroxylation reactions. It is important to handle this substance with care, as it may have biological effects and should be used under appropriate medical supervision. As with many steroid hormones, its use and dosage must be carefully monitored to avoid potential side effects.

Formula: C₂₁H₃₀O₃

InChI: InChI=1S/C21H30O3/c1-12(22)19-18(24)11-17-15-5-4-13-10-14(23)6-8-20(13,2)16(15)7-9-21(17,19)3/h10,15-19,24H,4-9,11H2,1-3H3/t15-,16+,17+,18-,19+,20+,21+/m1/s1

InChI key: InChIKey=LOVNYFVWYTXDRE-RMWFXKKMSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(CC3)=CC(=O)CC4)(CC1)[H])[H])(C[C@@H](O)[C@@H]2C(C)=O)[H]

Synonyms:

• (16Alpha)-16-Hydroxypregn-4-Ene-3,20-Dione
• (16Alpha,17Xi)-16-Hydroxypregn-4-Ene-3,20-Dione
• (16α)-16-Hydroxypregn-4-ene-3,20-dione
• 16α-Hydroxy-4-pregnene-3,20-dione
• 16α-Hydroxy-Δ⁴-pregnene-3,20-dione
• 16α-Hydroxyprogesterone
• NSC 523249
• NSC 53910
• Pregn-4-ene-3,20-dione, 16-hydroxy-, (16α)-
• Pregn-4-ene-3,20-dione, 16α-hydroxy-
• 16α-Hydroxy-Δ4-pregnene-3,20-dione
• 16-alfa-Hydroxy Progesterone
• 16α-Hydroxypregn-4-ene-3,20-dione

16α-HYDROXYPROGESTERONE

CAS: 438-07-3

Formula: C₂₁H₃₀O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 330.4611

Ref: IN-DA00DDE0

16-alfa-Hydroxy Progesterone

CAS: 438-07-3

Formula: C₂₁H₃₀O₃

Molecular weight: 330.47

Ref: 4Z-P-3298

16a-Hydroxy Progesterone

Controlled Product

CAS: 438-07-3

Stability Hygroscopic
Applications 16α-Hydroxyprrogesterone is a hydroxylated metabolite of Progesterone (P755900). 16α-Hydroxyprogesterone binds to human progesterone receptors hPR-A and hPR-B and act as an agonist for both receptors.
References Ikonen, M. et al.: Nature, 212, 716 (1966); Storbeck, K.-H. et al.: Mol. Cell. Endocrinol., 336, 92 (2011);

Formula: C₂₁H₃₀O₃

Color and Shape: Off-White

Molecular weight: 330.46

Ref: TR-H952430

16-alfa-Hydroxy Progesterone

CAS: 438-07-3

Formula: C₂₁H₃₀O₃

Molecular weight: 330.47

Ref: ST-EA-CP-P133083