CAS 438-59-5

10,11-Didehydronortriptyline hydrochloride

Description:

10,11-Didehydronortriptyline hydrochloride is a chemical compound that belongs to the class of tricyclic antidepressants. It is a derivative of nortriptyline, which is known for its use in the treatment of depression and certain types of pain. The compound features a tricyclic structure, which is characterized by three interconnected rings, contributing to its pharmacological activity. As a hydrochloride salt, it is typically more soluble in water, facilitating its use in pharmaceutical formulations. The compound acts primarily by inhibiting the reuptake of neurotransmitters such as norepinephrine and serotonin, thereby enhancing mood and alleviating depressive symptoms. Its chemical properties include a specific molecular weight and a defined melting point, which are essential for its characterization and quality control in pharmaceutical applications. Safety and efficacy profiles are critical, and like other tricyclic antidepressants, it may have side effects, including sedation and anticholinergic effects. Proper handling and dosage are essential to minimize risks associated with its use.

Formula: C₁₉H₂₀ClN

InChI: InChI=1/C19H19N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-13,20H,6,14H2,1H3;1H

InChI key: InChIKey=UZMPCPFDZYTEJG-UHFFFAOYSA-N

SMILES: C(CCNC)=C1C=2C(C=CC=3C1=CC=CC3)=CC=CC2.Cl

Synonyms:

• 1-Propanamine, 3-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-methyl-, hydrochloride (9CI)
• 1-Propanamine, 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-, hydrochloride
• 1-Propanamine, 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-, hydrochloride (1:1)
• 10,11-Didehydronortriptyline hydrochloride
• 10,11-thelda-Nortriptyline hydrochloride
• 3-(5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine hydrochloride (1:1)
• 5H-Dibenzo(a,d)cycloheptene-delta(sup 5),gamma-propylamine, N-methyl-, hydrochloride
• 5H-Dibenzo[a,d]cycloheptene-Δ^5,γ-propylamine, N-methyl-, hydrochloride
• N 7068 hydrochloride
• Norproheptatriene hydrochloride
• Ro 4-6011
• 3-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)propyl(methyl)ammonium chloride
• 5H-Dibenzo[a,d]cycloheptene-Δ5,γ-propylamine, N-methyl-, hydrochloride
• Nortriptyline Impurity 2 (Nortriptyline EP Impurity B)
• Cyclobenzaprine USP RC B Q: What is the storage condition of
• 3-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine Hydrochloride
• Einecs 207-118-3
• Cyclobenzaprine USP RC B
• Desmethyl Cyclobenzaprine Hydrochloride
• 3-(5H-Dibenzo[a,d][7]annulen-5-ylid
• Cyclobenzaprine Related CoMpound B
• Cyclobenzaprine Impurity 2(Cyclobenzaprine USP RC B)
• Cyclobenzaprine USP Related Compound B as Hydrochloride
• N-desmethyl Cyclobenzaprine HCl (USP RC B)
• Nortriptyline EP Impurity B HCl
• Cyclobenzaprine impurity 2/Cyclobenzaprine USP Related Compound B/Desmethyl Cyclobenzaprine Hydrochloride/3-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine hydrochloride
• NORTRIPTYLINE EP IMPURITY B
• Cyclobenzaprine USP RC B Q: What is the CAS Number of
• Nortriptyline EP Impurity B HCl (N-Desmethyl Cyclobenzaprine HCl)
• Nortriptyline Hydrochloride Impurity B as Hydrochloride
• N-Desmethyl Cyclobenzaprine
• 3-(dibenzo[1,2-a:1',2'-e][7]annulen-11-ylidene)-N-methylpropan-1-amine
• N-Desmethyl Cyclobenzaprine Hydrochloride
• Nortriptyline Hydrochloride EP Impurity B as Hydrochloride
• Cyclobenzaprine USP Related Compound B
• Cyclobenzaprine DesMethyl HCl
• N-Desmethylcyclobenzaprine hydrochloride solution
• N-Desmethyl Cyclobenzaprine-d3
• Cyclobenzaprine Related Compound B (3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine (1154525)
• Cyclobenzaprine Related Compound B (10 mg) (3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine, hydrochloride)
• Cyclobenzaprine USP RC B Q: What are the applications of
• Desmethylcyclobenzaprine hydrochloride salt
• Cyclobenzaprine USP RC BQ: What is
• Cyclobenzaprine Related Compound B as Hydrochloride

N-Desmethylcyclobenzaprine Hydrochloride (Norcyclobenzaprine Hydrochloride) 1.0 mg/ml in Methanol (as free base)

CAS: 438-59-5

Color and Shape: Single Solution

Ref: 61-AMP0079.01-01

Cyclobenzaprine Related Compound B (3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine, hydrochloride)

CAS: 438-59-5

Aromatic monoamines and their derivatives, salts thereof, nesoi

Formula: C₁₉H₁₉N·HCl

Color and Shape: White Powder

Molecular weight: 261.15175

Ref: 45-1154525

1-Propanamine,3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-,hydrochloride (1:1)

CAS: 438-59-5

Formula: C₁₉H₂₀ClN

Color and Shape: Solid

Molecular weight: 297.8218

Ref: IN-DA0037GQ

Nortriptyline EP Impurity B HCl (Cyclobenzaprine USP Related Compound B, N-Desmethyl Cyclobenzaprine HCl)

CAS: 438-59-5

Formula: C₁₉H₁₉N·HCl

Molecular weight: 261.37 36.46

Ref: 4Z-N-3621

3-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine Hydrochloride (Norcyclobenzaprine Hydrochloride)

Controlled Product

CAS: 438-59-5

Formula: C₁₉H₁₉N·ClH

Color and Shape: Neat

Molecular weight: 297.82

Ref: 86-MM0079.01

Desmethyl Cyclobenzaprine Hydrochloride

CAS: 438-59-5

Impurity Cyclobenzaprine USP Related Compound B
Applications Desmethyl Cyclobenzaprine (Cyclobenzaprine USP Related Compound B) is a metabolite of Cyclobenzaprine.
References Wang, R.W., et al.: Drug Metab. Dispos., 24, 786 (1996),

Formula: C₁₉H₁₉N·ClH

Color and Shape: Off-White

Molecular weight: 297.82

Ref: TR-D291560

Nortriptyline EP Impurity B

CAS: 438-59-5

Formula: C₁₉H₁₉NHCl

Molecular weight: 261.37 : 36.46

Ref: ST-EA-CP-N15002

Desmethyl cyclobenzaprine hydrochloride

CAS: 438-59-5

Desmethyl cyclobenzaprine hydrochloride is a metabolite of cyclobenzaprine, a drug used for the treatment of muscle spasms. Desmethyl cyclobenzaprine hydrochloride has been shown to have an increased potency for the termination of nerve impulses. These results were determined by in vivo studies using an assay on rat sciatic nerve and a study on human adrenergic receptors. This metabolite also shows potentiation effects with other drugs such as clonidine and prazosin, which are used to treat hypertension and anxiety, respectively. However, clinical relevance is still unknown due to the lack of data on desmethyl cyclobenzaprine hydrochloride's uptake and enhancement in humans.

Formula: C₁₉H₂₀ClN

Purity: Min. 95%

Color and Shape: White To Off-White Solid

Molecular weight: 297.82 g/mol

Ref: 3D-FD21256