CAS 438-60-8

protriptyline

Description:

Protriptyline is a tricyclic antidepressant primarily used in the treatment of major depressive disorder. It functions by inhibiting the reuptake of neurotransmitters, particularly norepinephrine and serotonin, thereby enhancing mood and alleviating depressive symptoms. Protriptyline is characterized by its chemical structure, which includes a three-ring system typical of tricyclic compounds. It is a white to off-white crystalline powder that is soluble in water and exhibits a moderate lipophilicity, allowing it to cross the blood-brain barrier effectively. The substance has a relatively long half-life, which can influence dosing schedules. Common side effects may include dry mouth, constipation, and sedation, among others, due to its anticholinergic properties. Protriptyline is also noted for its potential to cause cardiovascular effects, necessitating caution in patients with pre-existing heart conditions. As with all medications, it is essential to use protriptyline under the guidance of a healthcare professional to manage dosage and monitor for adverse effects.

Formula: C₁₉H₂₁N

InChI: InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3

InChI key: InChIKey=BWPIARFWQZKAIA-UHFFFAOYSA-N

SMILES: C(CCNC)C1C=2C(C=CC=3C1=CC=CC3)=CC=CC2

Synonyms:

• 3-(Dibenzo(A,D)Cyclohepten-5-Yl)Propylmethylamine
• 5-(3-Methylaminopropyl)-5H-dibenzo[a,d]cycloheptene
• 5H-Dibenzo[a,d]cycloheptene-5-propanamine, N-methyl-
• 5H-Dibenzo[a,d]cycloheptene-5-propylamine, N-methyl-
• 7-(3-Methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene
• Amimetilina
• Mk 240
• N-3-(5H-Dibenzo[a,d]cyclohepten-5-yl)propyl-N-methylamine
• N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine
• N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine
• Protriptilina
• Protriptylin
• Protryptyline
• Triptil
• Vivactil
• 3-(5H-Dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine
• Protriptyline-d6
• Protriptyline 13CD3
• DIBENZO(A,D)CYCLOHEPTENE-5-PROPYLAMINE,N-METHYL-
• PROTRIPTYLINE
• PROTRIPTYLINEHYDROCHLORIDE,1.0MG/ML(FREEBASE)INMETHANOL
• 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine

Protriptyline-d3

CAS: 438-60-8

Formula: C₁₉H₁₈ND₃

Molecular weight: 266.42

Ref: 4Z-P-433

Protriptyline-d6

CAS: 438-60-8

Formula: C₁₉H₁₅ND₆

Molecular weight: 269.45

Ref: 4Z-P-432

Protriptyline

CAS: 438-60-8

Protriptyline: Antidepressant, AChE inhibitor (IC50 0.06 mM), prevents Aβ aggregation; potential for depression and Alzheimer's.

Formula: C₁₉H₂₁N

Color and Shape: Solid

Molecular weight: 263.38

Ref: TM-T60430