CAS 439081-17-1

2-Butenamide,N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-

Description:

The chemical substance known as 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, with the CAS number 439081-17-1, is a complex organic compound characterized by its multi-functional structure. It features a quinazoline core, which is a bicyclic compound known for its biological activity, particularly in medicinal chemistry. The presence of a chloro and a fluoro substituent on the phenyl ring suggests potential interactions with biological targets, enhancing its pharmacological properties. The dimethylamino group contributes to its basicity, potentially influencing solubility and reactivity. Additionally, the tetrahydrofuran moiety indicates the presence of an ether linkage, which may affect the compound's conformational flexibility and interaction with biological systems. Overall, this compound's unique structural features suggest it may possess significant activity in therapeutic applications, although specific biological data would be necessary to fully understand its potential uses and mechanisms of action.

Formula: C₂₄H₂₅ClFN₅O₃

R-Afatinib

CAS: 439081-17-1

Irreversible blocker of three members of the ErbB family (ErbB1, ErbB2/HER2, and ErbB4) with IC50 in nanomolar range. The compound binds covalently to cysteine 797 residue in HER2 and blocks downstream cellular signalling, inhibits cellular growth and promotes apoptosis. Afatinib has been used for the treatment of tyrosine kinase inhibitor-resistant tumours with mutations in ErbB genes, especially for deletions in exon 19 and single nucleotide substitutions in exon 21. It has been used for treatment of non-small cell lung cancer (NSCLC), breast cancer, pancreatic cancer, colorectal cancer, etc.

Formula: C₂₄H₂₅ClFN₅O₃

Purity: Min. 95%

Color and Shape: White To Off-White Solid

Molecular weight: 485.94 g/mol

Ref: 3D-FA103643

(R)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

CAS: 439081-17-1

Formula: C₂₄H₂₅ClFN₅O₃

Molecular weight: 485.94

Ref: ST-EA-CP-A50078

(R)-Afatinib

CAS: 439081-17-1

(R)-Afatinib: oral ErbB inhibitor (EGFR/HER2), IC50 ≤14 nM. For ESCC, NSCLC, gastric cancer research.

Formula: C₂₄H₂₅ClFN₅O₃

Color and Shape: Solid

Molecular weight: 485.94

Ref: TM-T72912