CAS 439239-90-4

Lasmiditan

Description:

Lasmiditan is a novel medication primarily used for the acute treatment of migraine. It belongs to a class of drugs known as ditans, which are designed to target specific serotonin receptors, particularly the 5-HT_1F receptor, to alleviate migraine symptoms without causing vasoconstriction, a common side effect associated with traditional triptans. The chemical formula of lasmiditan reflects its complex structure, which includes multiple functional groups that contribute to its pharmacological activity. It is characterized by its high selectivity for the aforementioned receptor, which helps in reducing the incidence of side effects typically associated with migraine treatments. Lasmiditan is administered orally and has a relatively rapid onset of action, making it effective for acute migraine relief. Its safety profile has been evaluated in clinical trials, demonstrating a favorable balance between efficacy and tolerability. As with any medication, it is essential for patients to consult healthcare professionals regarding its use, potential interactions, and contraindications.

Formula: C₁₉H₁₈F₃N₃O₂

InChI: InChI=1S/C19H18F3N3O2/c1-25-7-5-11(6-8-25)18(26)15-3-2-4-16(23-15)24-19(27)17-13(21)9-12(20)10-14(17)22/h2-4,9-11H,5-8H2,1H3,(H,23,24,27)

InChI key: InChIKey=XEDHVZKDSYZQBF-UHFFFAOYSA-N

SMILES: C(=O)(C=1N=C(NC(=O)C2=C(F)C=C(F)C=C2F)C=CC1)C3CCN(C)CC3

Synonyms:

• Lasmiditan
• 2,4,6-Trifluoro-N-[6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridinyl]benzamide
• COL 144
• LY 573144
• Benzamide, 2,4,6-trifluoro-N-[6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridinyl]-
• LasMiditan (COL-144
• LY573144
• COL-144; LY573144
• 2,4-difluoro-N-(6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl)benzamide
• Lasmiditant
• 2,4,6-trifluoro-N-(6-(1-Methylpiperidine-4-carbonyl)pyridin-2-yl)benzaMide
• COL-144; LY-573144;COL144; LY 573144

Lasmiditan-13C-d2

CAS: 439239-90-4

Formula: C₁₈₁₃CH₁₆D₂F₃N₃O₂

Molecular weight: 380.37

Ref: 4Z-L-185002

Lasmiditan

Controlled Product

CAS: 439239-90-4

Applications Lasmiditan is used in diagnosing, treating and/or preventing periodontal disease and/or tooth loss. References Offenbacher, Steven. et al., U.S. Pat. Appl. Publ.(2020);

Formula: C₁₉H₁₈F₃N₃O₂

Color and Shape: Neat

Molecular weight: 377.36

Ref: TR-L357010

Lasmiditan

CAS: 439239-90-4

Serotonin receptor agonist with selective binding to the 5-HT1F receptor subtype

Formula: C₁₉H₁₈F₃N₃O₂

Purity: Min. 95%

Molecular weight: 377.36 g/mol

Ref: 3D-FL102251

Lasmiditan

CAS: 439239-90-4

Formula: C₁₉H₁₈F₃N₃O₂

Color and Shape: White To Off-White Solid

Molecular weight: 377.37

Ref: 4Z-L-185001