CAS 4394-00-7

Niflumic acid

Description:

Niflumic acid is a non-steroidal anti-inflammatory drug (NSAID) primarily used for its analgesic and anti-inflammatory properties. It belongs to the class of arylacetic acids and is characterized by its ability to inhibit cyclooxygenase enzymes, which play a crucial role in the synthesis of prostaglandins involved in inflammation and pain signaling. The chemical structure of niflumic acid features a 2,6-difluorobenzamide moiety, contributing to its pharmacological activity. It is typically administered in oral form and is known for its relatively rapid absorption and metabolism. Niflumic acid exhibits a range of therapeutic effects, including the alleviation of pain associated with various conditions such as arthritis and dysmenorrhea. However, like other NSAIDs, it may be associated with gastrointestinal side effects and cardiovascular risks, necessitating careful consideration of its use in patients with pre-existing conditions. Its CAS number, 4394-00-7, is a unique identifier that facilitates the identification and study of this compound in scientific literature and regulatory contexts.

Formula: C₁₃H₉F₃N₂O₂

InChI: InChI=1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20)

InChI key: InChIKey=JZFPYUNJRRFVQU-UHFFFAOYSA-N

SMILES: N(C1=C(C(O)=O)C=CC=N1)C2=CC(C(F)(F)F)=CC=C2

Synonyms:

• 2-(Alpha,Alpha,Alpha-Trifluoro-M-Toluidino)Nicotinic Acid
• 2-[3-(Trifluoromethyl)-phenyl]aminonicotinic acid
• 2-[3-(Trifluoromethyl)anilino]-3-pyridinecarboxylic acid
• 2-[3-(Trifluoromethyl)anilino]nicotinic acid
• 2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid
• 2-{[3-(Trifluoromethyl)Phenyl]Amino}Nicotinic Acid
• 2-{[3-(Trifluoromethyl)Phenyl]Amino}Pyridine-3-Carboxylate
• 3-Pyridinecarboxylic acid, 2-[[3-(trifluoromethyl)phenyl]amino]-
• Acide Niflumique
• Acido Niflumico
• Actol
• Actol (analgesic)
• Donalgin
• Flogovital
• Forenol
• Landruma
• N-(α,α,α-Trifluoro-m-tolyl)nicotinic acid
• Nicotinic acid, 2-(α,α,α-trifluoro-m-toluidino)-
• Niflamol
• Nifluminic acid
• Nifluminsaure
• Nifluril
• Up 83

Niflumic Acid

CAS: 4394-00-7

Formula: C₁₃H₉F₃N₂O₂

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 282.22

Ref: 3B-T2353

Niflumic acid, 99+%

CAS: 4394-00-7

It is used as a selective Cox-2 inhibitor and GPR35 activator. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label info

Formula: C₁₃H₉F₃N₂O₂

Purity: 99+%

Color and Shape: Powder or crystals or crystalline powder

Molecular weight: 282.22

Ref: 02-J60489

Niflumic Acid

CAS: 4394-00-7

Color and Shape: Neat

Ref: 61-FOR0850.00

NIFLUMIC ACID CRS

CAS: 4394-00-7

NIFLUMIC ACID CRS

Formula: C₁₃H₉F₃N₂O₂

Color and Shape: Crystalline Powder. Light Yellow. Powder.

Molecular weight: 282.218

Ref: 41-Y0000824

2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid

CAS: 4394-00-7

Formula: C₁₃H₉F₃N₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 282.2180

Ref: IN-DA003T3S

Niflumic acid

CAS: 4394-00-7

Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.

Formula: C₁₃H₉F₃N₂O₂

Purity: 99.47%

Color and Shape: Solid

Molecular weight: 282.22

Ref: TM-T0693

Niflumic acid

CAS: 4394-00-7

Niflumic acid

Purity: ≥98%

Molecular weight: 282.22g/mol

Ref: 54-BUP14952

Niflumic acid

CAS: 4394-00-7

Niflumic acid

Purity: 98%

Molecular weight: 282.22g/mol

Ref: 54-PC908706

Niflumic acid

CAS: 4394-00-7

Formula: C₁₃H₉F₃N₂O₂

Molecular weight: 282.22

Ref: 7W-GL5205

Niflumic acid

Controlled Product

CAS: 4394-00-7

Formula: C₁₃H₉F₃N₂O₂

Color and Shape: Neat

Molecular weight: 282.22

Ref: 04-C15522500

Niflumic Acid

Controlled Product

CAS: 4394-00-7

Formula: C₁₃H₉F₃N₂O₂

Color and Shape: Neat

Molecular weight: 282.22

Ref: 86-MM0850.00

Niflumic Acid

CAS: 4394-00-7

Formula: C₁₃H₉F₃N₂O₂

Color and Shape: Off-White Solid

Molecular weight: 282.22

Ref: 4Z-N-123001

Niflumic Acid

Controlled Product

CAS: 4394-00-7

Applications Anti-inflammatory. Selective cyclooxygenase-2 (COX-2) inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Glasson, et al.: Biochem, Pharmacol., 18, 633 (1969), Boissier, et al.: Therapie, 26, 211 (1971), Sorenson, J.R.J., et al.: J. Med. Chem., 19, 135 (1976), Barnett, J., et al.: Biochim. Biophys. Acta, 1209, 130 (1994), Johnson, J.L., et al.: Arch. Biochem. Biophys., 324, 26 (1995),

Formula: C₁₃H₉F₃N₂O₂

Color and Shape: Light Yellow

Molecular weight: 282.22

Ref: TR-N457500

Niflumic acid

CAS: 4394-00-7

Niflumic acid is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits the function of cyclooxygenase and 5-lipoxygenase. It has been shown to inhibit P-glycoprotein (P-gp) in vitro. Inhibition of P-gp leads to an increase in the intracellular levels of Ca2+ and activation of the ryanodine receptor, which is a protein found on the endoplasmic reticulum. This results in an increase in cellular excitability, which can lead to cell death. Niflumic acid also inhibits picolinic acid and pyrazinoic acid production, which are toxic metabolites that may play a role in its anti-inflammatory effects.

Formula: C₁₃H₉F₃N₂O₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 282.22 g/mol

Ref: 3D-FN26214

Niflumic Acid

CAS: 4394-00-7

M02156 - Niflumic Acid

Formula: C₁₃H₉F₃N₂O₂

Purity: 95%

Color and Shape: Solid, Slightly pale yellow to yellow powder

Molecular weight: 282.222

Ref: 10-M02156