CAS 440327-46-8

Thymidine, 5'-(4-oxopentanoate)

Description:

Thymidine, 5'-(4-oxopentanoate), identified by the CAS number 440327-46-8, is a derivative of thymidine, which is a nucleoside composed of the base thymine and the sugar deoxyribose. This particular compound features a 4-oxopentanoate moiety attached to the 5' position of the thymidine molecule, which introduces a carboxylic acid derivative that can influence its biochemical properties and reactivity. The presence of the 4-oxopentanoate group may enhance its solubility and alter its interaction with biological systems, potentially affecting its role in nucleic acid synthesis or as a substrate in enzymatic reactions. Thymidine derivatives are often studied for their applications in molecular biology, particularly in the context of DNA synthesis and repair. Additionally, the structural modifications can impact the compound's stability, bioavailability, and pharmacological properties, making it of interest in medicinal chemistry and drug development. As with many nucleoside analogs, understanding its characteristics is crucial for exploring its potential therapeutic applications.

Formula: C₁₅H₂₀N₂O₇

5'-O-Levulinoylthymidine

CAS: 440327-46-8

5'-O-Levulinoylthymidine is a novel nucleoside analog that inhibits viral proliferation by inhibiting viral RNA polymerase. This drug is also an activator of ribonucleotide reductases, which are enzymes that synthesize deoxyribonucleotides from ribonucleotides. 5'-O-Levulinoylthymidine has been shown to inhibit the growth of cancer cells in vitro and in vivo. It has also been shown to be effective against HIV-1 infection in vitro.

Formula: C₁₅H₂₀N₂O₇

Purity: Min. 95%

Color and Shape: White Off-White Powder

Molecular weight: 340.33 g/mol

Ref: 3D-NL06916