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CAS 441785-25-7

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Besifovir

Description:
Besifovir is an antiviral compound primarily investigated for its potential use in the treatment of hepatitis B virus (HBV) infections. It belongs to the class of nucleoside analogs, which function by inhibiting viral replication. The chemical structure of besifovir features a modified nucleoside backbone, which enhances its efficacy against HBV. Its mechanism of action involves the selective inhibition of the viral polymerase, thereby disrupting the viral life cycle. Besifovir has demonstrated a favorable pharmacokinetic profile, including good oral bioavailability and a long half-life, which supports its potential for once-daily dosing. Additionally, it has shown a lower propensity for developing resistance compared to some other antiviral agents. Safety and tolerability studies indicate that besifovir may have a manageable side effect profile, although ongoing clinical trials are essential to fully establish its therapeutic potential and long-term effects. Overall, besifovir represents a promising candidate in the ongoing search for effective treatments for chronic hepatitis B infection.
Formula:C10H14N5O4P
InChI:InChI=1S/C10H14N5O4P/c11-9-12-3-7-8(14-9)15(5-13-7)4-10(1-2-10)19-6-20(16,17)18/h3,5H,1-2,4,6H2,(H2,11,12,14)(H2,16,17,18)
InChI key:InChIKey=KDNSSKPZBDNJDF-UHFFFAOYSA-N
SMILES:C(C1(OCP(=O)(O)O)CC1)N2C=3C(N=C2)=CN=C(N)N3
Synonyms:
  • ((1-((2-Amino-9H-purin-9-yl)methyl)cyclopropoxy)methyl)phosphonic acid
  • ((1-((2-Amino-9H-purin-9-yl)methyl)cyclopropoxy)methyl)phosphonicacid
  • Besifovir
  • Lb-80331
  • P-[[[1-[(2-Amino-9H-purin-9-yl)methyl]cyclopropyl]oxy]methyl]phosphonic acid
  • Phosphonic acid, P-[[[1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl]oxy]methyl]-
  • Phosphonic acid, [[[1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl]oxy]methyl]-
  • [({1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl}oxy)methyl]phosphonic acid
  • Phosphonic Acid, [[[1-[(2-Amino-9h-Purin-9-Yl)Methyl]Cyclopropyl]Oxy]Methyl]-(9ci)
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Found 4 products.