CAS 441798-33-0

Macitentan

Description:

Macitentan is a synthetic compound classified as an endothelin receptor antagonist, primarily used in the treatment of pulmonary arterial hypertension (PAH). It selectively inhibits the endothelin-1 receptors, which play a significant role in vasoconstriction and vascular remodeling. Macitentan is characterized by its high affinity for both endothelin A and B receptors, contributing to its therapeutic effects by promoting vasodilation and reducing blood pressure in the pulmonary arteries. The substance is typically administered orally and has a long half-life, allowing for once-daily dosing. Its chemical structure includes a sulfonamide group, which is essential for its biological activity. Macitentan is known for its favorable safety profile, although it may cause side effects such as headache, anemia, and liver enzyme elevations. Due to its mechanism of action, it is often used in combination with other PAH therapies to enhance treatment efficacy. Overall, Macitentan represents a significant advancement in the management of pulmonary arterial hypertension, improving patients' quality of life and exercise capacity.

Formula: C₁₉H₂₀Br₂N₆O₄S

InChI: InChI=1S/C19H20Br2N6O4S/c1-2-7-26-32(28,29)27-17-16(13-3-5-14(20)6-4-13)18(25-12-24-17)30-8-9-31-19-22-10-15(21)11-23-19/h3-6,10-12,26H,2,7-9H2,1H3,(H,24,25,27)

InChI key: InChIKey=JGCMEBMXRHSZKX-UHFFFAOYSA-N

SMILES: N(S(NCCC)(=O)=O)C=1C(=C(OCCOC=2N=CC(Br)=CN2)N=CN1)C3=CC=C(Br)C=C3

Synonyms:

• Act 064992
• N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide
• Opsumit
• Propylsulfamic acid N-[5-(4-bromophenyl)-6-[2-[(5-bromopyrimidin-2-yl)oxy]ethoxy]pyrimidin-4-yl]amide
• Sulfamide, N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N′-propyl-
• Macitentan

Macitentan

CAS: 441798-33-0

Macitentan

Purity: ≥98%

Molecular weight: 588.27g/mol

Ref: 54-BUP13655

Macitentan

CAS: 441798-33-0

Macitentan

Purity: 98%

Molecular weight: 588.27g/mol

Ref: 54-OR1027414

Macitentan

CAS: 441798-33-0

Formula: C₁₉H₂₀Br₂N₆O₄S

Color and Shape: Off-White Solid

Molecular weight: 588.28

Ref: 4Z-M-128001

Macitentan

CAS: 441798-33-0

Color and Shape: Neat

Ref: 86-MM3908.00

Macitentan-d11

CAS: 441798-33-0

Formula: C₁₉H₉D₁₁Br₂N₆O₄S

Molecular weight: 599.34

Ref: 4Z-M-128066

Macitentan

CAS: 441798-33-0

Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).

Formula: C₁₉H₂₀Br₂N₆O₄S

Purity: 98% - >99.99%

Color and Shape: Solid

Molecular weight: 588.27

Ref: TM-T2561

Macitentan-d7

CAS: 441798-33-0

Formula: C₁₉H₁₃Br₂N₆O₄SD₇

Molecular weight: 595.32

Ref: 4Z-M-128013

Macitentan

Controlled Product

CAS: 441798-33-0

Applications Macitentan, is an orally active endothelin receptor antagonist used for pulmonary arterial hypertension.
References Emoto, N. Ensho to Men'eki, 20, 487 (2012);

Formula: C₁₉H₂₀Br₂N₆O₄S

Color and Shape: White To Off-White

Molecular weight: 588.27

Ref: TR-M105005

Macitentan - Bio-X ™

CAS: 441798-33-0

Macitentan is an endothelial receptor antagonist that is used in the management of pulmonary arterial hypertension in order to delay progression of disease. This drug binds to endothelial receptors blocking signalling from endothelial -1 and -2.

Formula: C₁₉H₂₀Br₂N₆O₄S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 588.27 g/mol

Ref: 3D-BM162771

Macitentan

CAS: 441798-33-0

Endothelin receptor antagonist for treatment of pulmonary arterial hypertension

Formula: C₁₉H₂₀Br₂N₆O₄S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 588.27 g/mol

Ref: 3D-FM65071