CAS 443104-02-7

28-(1H-Imidazol-1-yl)-3,12,28-trioxooleana-1,9(11)-diene-2-carbonitrile

Description:

The chemical substance known as 28-(1H-Imidazol-1-yl)-3,12,28-trioxooleana-1,9(11)-diene-2-carbonitrile, with the CAS number 443104-02-7, is a synthetic compound that belongs to the class of triterpenoids, specifically derived from oleanolic acid. This compound features a complex structure characterized by multiple functional groups, including imidazole, carbonitrile, and trioxo moieties, which contribute to its potential biological activity. The presence of the imidazole ring suggests possible interactions with biological targets, making it of interest in medicinal chemistry. The trioxo groups may enhance its reactivity and influence its pharmacological properties. Additionally, the oleane skeleton provides a rigid framework that can affect the compound's conformation and stability. Research into this compound may focus on its potential applications in drug development, particularly in the context of anti-inflammatory or anticancer activities, although specific biological data would be necessary to elucidate its efficacy and safety profile. Overall, this compound exemplifies the intricate relationship between chemical structure and biological function in the realm of pharmaceutical chemistry.

Formula: C₃₄H₄₃N₃O₃

Synonyms:

• CDDO-Im
• CDDO-Imidazolide
• 1-[2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl]-1H-imidazole

TP 235

CAS: 443104-02-7

Formula: C₃₄H₄₃N₃O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 541.7235

Ref: IN-DA00DB5F

CDDO-Im

CAS: 443104-02-7

CDDO-Im

Purity: ≥95%

Molecular weight: 541.72g/mol

Ref: 54-BUP12605

(4Ar,6As,6Br,8As,12As,12Br,14Bs)-8A-(1H-Imidazole-1-Carbonyl)-4,4,6A,6B,11,11,14B-Heptamethyl-3,13-Dioxo-3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-Octadecahydropicene-2-Carbonitrile

CAS: 443104-02-7

(4Ar,6As,6Br,8As,12As,12Br,14Bs)-8A-(1H-Imidazole-1-Carbonyl)-4,4,6A,6B,11,11,14B-Heptamethyl-3,13-Dioxo-3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-Octadecahydropicene-2-Carbonitrile

Purity: 98%

Molecular weight: 541.72g/mol

Ref: 54-OR1023034

CDDO-Im

CAS: 443104-02-7

CDDO-Im (TP-235) is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).

Formula: C₃₄H₄₃N₃O₃

Purity: 98.3% - 99.61%

Color and Shape: Solid

Molecular weight: 541.72

Ref: TM-TQ0120

CDDO Imidazolide

Controlled Product

CAS: 443104-02-7

Stability Light Sensitive
Applications CDDO Imidozolide (CDDO-Im) is a synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells. Studies show that CDDO-Im is highly active in suppressing cellular proliferation of human leukemia and breast cancer cell lines as well as being an effective therapeutic agent in the treatment of other types of cancers.
References Hughes, D.T. et al.: Cancer Invest., 26, 118 (2008); Place, A.E. et al.: Clin. Cancer Res., 9, 2798 (2003); Samudio, I. et al.: J. Biol. Chem., 280, 36273 (2005);

Formula: C₃₄H₄₃N₃O₃

Color and Shape: Neat

Molecular weight: 541.72

Ref: TR-C228090

CDDO Im

CAS: 443104-02-7

CDDO Im is a natural compound that has potent antitumor activity and anti-inflammatory properties. CDDO Im may also be useful in the treatment of inflammatory bowel disease by inhibiting the production of chemokines and inducing apoptosis in colonic epithelial cells. It inhibits the activation of NF-κB, which is a transcription factor that regulates the expression of many genes involved in inflammation, including cytokines and adhesion molecules. CDDO Im also inhibits epidermal growth factor (EGF) signaling and cell proliferation. This compound can also induce apoptosis via reactive oxygen species. CDDO Im has been shown to inhibit the lps-induced inflammatory response by decreasing pro-inflammatory cytokine levels and preventing neutrophil infiltration into the gut mucosa.

Formula: C₃₄H₄₃N₃O₃

Purity: Min. 95%

Molecular weight: 541.72 g/mol

Ref: 3D-TSA10402