COX-2/15-LOX-IN-5, with the CAS number 443790-30-5, is a chemical compound that serves as an inhibitor of cyclooxygenase-2 (COX-2) and lipoxygenase-15 (15-LOX). These enzymes are involved in the inflammatory process and the metabolism of arachidonic acid, leading to the production of various eicosanoids, which play significant roles in inflammation and pain. The inhibition of COX-2 is particularly relevant in the context of pain relief and anti-inflammatory effects, while 15-LOX inhibition may contribute to additional therapeutic benefits in conditions related to oxidative stress and inflammation. The compound is typically studied for its potential applications in treating inflammatory diseases, cancer, and other conditions where modulation of the eicosanoid pathway is beneficial. Its pharmacological profile may include properties such as anti-inflammatory, analgesic, and possibly anticancer effects, although specific biological activities and mechanisms of action would require further investigation through experimental studies.

COX-2/15-LOX-IN-5

443790-30-5: COX-2/15-LOX-IN-5, with the CAS number 443790-30-5, is a chemical compound that serves as an inhibitor of cyclooxygenase-2 (COX-2) and lipoxygenase-15 (15-LOX). These enzymes are involved in the inflammatory process and the metabolism of arachidonic acid, leading to the production of various eicosanoids, which play significant roles in inflammation and pain. The inhibition of COX-2 is particularly relevant in the context of pain relief and anti-inflammatory effects, while 15-LOX inhibition may contribute to additional therapeutic benefits in conditions related to oxidative stress and inflammation. The compound is typically studied for its potential applications in treating inflammatory diseases, cancer, and other conditions where modulation of the eicosanoid pathway is beneficial. Its pharmacological profile may include properties such as anti-inflammatory, analgesic, and possibly anticancer effects, although specific biological activities and mechanisms of action would require further investigation through experimental studies.

<p>COX-2/15-LOX-IN-5 (Compound 4f) functions as a dual inhibitor of COX-2 and 15-LOX, demonstrating both anti-inflammatory and antioxidant properties [1]. This compound effectively reduces NF-κB activation in RAW 264.7 macrophages that is induced by lipopolysaccharide.</p>

CAS 443790-30-5

COX-2/15-LOX-IN-5

COX-2/15-LOX-IN-5

Ref: TM-T86081