CAS 443913-73-3: Vandetanib
Description:Vandetanib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of medullary thyroid carcinoma. It targets multiple receptor tyrosine kinases, including vascular endothelial growth factor receptor (VEGFR), epidermal growth factor receptor (EGFR), and rearranged during transfection (RET), which are involved in tumor growth and angiogenesis. The chemical formula of vandetanib is C22H24N4O2S, and it has a molecular weight of approximately 396.52 g/mol. This compound is typically administered orally and exhibits a moderate to high bioavailability. Vandetanib is known for its potential side effects, which may include diarrhea, hypertension, fatigue, and skin rashes, among others. Its mechanism of action involves the inhibition of tumor cell proliferation and the reduction of blood supply to tumors, making it a valuable therapeutic option in oncology. As with any medication, its use should be closely monitored by healthcare professionals to manage any adverse effects and ensure efficacy.
Formula:C22H24BrFN4O2
InChI:InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
InChI key:InChIKey=UHTHHESEBZOYNR-UHFFFAOYSA-N
SMILES:FC1=CC(Br)=CC=C1NC=2N=CN=C3C=C(OCC4CCN(C)CC4)C(OC)=CC32
- Synonyms:
- 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline
- 4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-
- Azd-6474
- Azd6474
- Caprelsa
- Ch 331
- N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazolin-4-amine
- N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-(N-methylpiperidin-4-ylmethoxy)quinazolin-4-amine
- N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine
- N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
- See more synonyms
- N-(4-bromo-2-fluoro-phenyl)-6-methoxy-7-[(1-methyl-4-piperidyl)methoxy]quinazolin-4-amine
- Vandetanib, Zactima, ZD6474
- Zactima
- Zd-6474
- Vandetanib
