CAS 4442-59-5

2-Aminomethyl-1,4-benzodioxane

Description:

2-Aminomethyl-1,4-benzodioxane, with the CAS number 4442-59-5, is an organic compound characterized by its unique structure that includes a benzodioxane moiety and an amino group. This compound typically appears as a white to off-white solid and is soluble in polar solvents, such as water and alcohols, due to the presence of the amino group, which can engage in hydrogen bonding. The benzodioxane structure contributes to its potential biological activity, making it of interest in medicinal chemistry. It may exhibit properties such as being a potential intermediate in the synthesis of pharmaceuticals or other organic compounds. The presence of the amino group can also impart basicity, allowing it to participate in various chemical reactions, including nucleophilic substitutions. Safety data should be consulted for handling, as with any chemical substance, to ensure proper precautions are taken due to potential toxicity or reactivity. Overall, 2-Aminomethyl-1,4-benzodioxane is a compound of interest in both synthetic and medicinal chemistry contexts.

Formula: C₉H₁₁NO₂

InChI: InChI=1S/C9H11NO2/c10-5-7-6-11-8-3-1-2-4-9(8)12-7/h1-4,7H,5-6,10H2

InChI key: InChIKey=JHNURUNMNRSGRO-UHFFFAOYSA-N

SMILES: C(N)C1OC=2C(OC1)=CC=CC2

Synonyms:

• (2,3-Dihydro-1,4-benzodioxin-2-yl)methanamine
• (2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methanamine
• (2R)-2,3-dihydro-1,4-benzodioxin-2-ylmethanaminium
• (2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethanaminium
• (±)-2-(Aminomethyl)-1,4-benzodioxane
• 1,4-Benzodioxan, 2-(aminomethyl)-
• 1,4-Benzodioxan-2-methylamine
• 1,4-Benzodioxane-2-methylamine
• 1,4-Benzodioxin-2-methanamine, 2,3-dihydro-
• 1-(2,3-Dihydro-1,4-Benzodioxin-2-Yl)Methanamine
• 2,3-Dihydro-1,4-benzodioxin-2-methanamine
• 2,3-Dihydro-1,4-benzodioxin-2-ylmethanamine
• 2,3-Dihydro-1,4-benzodioxin-3-ylmethanamine
• 2-(Aminomethyl)-1,4-benzodioxan
• 2-Aminomethyl-2,3-dihydro-1,4-benzodioxin
• 946F
• Aminomethylbenzodioxan
• Brn 0150152
• Fourneau 946
• LP 1 (pharmaceutical)
• Lp 1
• N-[(2,3-Dihydrobenzo[1,4]dioxin-2-yl)methyl]amine
• Nsc 116045
• [(2,3-Dihydro-1,4-benzdioxin-2-yl)methyl]amine
• [(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]amine

(2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methanamine

CAS: 4442-59-5

Formula: C₉H₁₁NO₂

Purity: 97%

Color and Shape: Liquid

Molecular weight: 165.1891

Ref: IN-DA003VGM

2-(Aminomethyl)-2,3-dihydro-1,4-benzodioxine

CAS: 4442-59-5

2-(Aminomethyl)-2,3-dihydro-1,4-benzodioxine

Formula: C₉H₁₁NO₂

Purity: 97%

Color and Shape: straw colourled oil

Molecular weight: 165.19g/mol

Ref: 54-OR3418

2,3-Dihydro-1,4-benzodioxin-2-ylmethylamine

CAS: 4442-59-5

2,3-Dihydro-1,4-benzodioxin-2-ylmethylamine (DHBMA) is a pharmacophore that has been shown to be an epileptic and convulsant in epidemiological studies. This drug binds to the receptor binding site of the Na+/K+ ATPase enzyme and inhibits its binding affinity for sodium ions. DHBMA has been shown to increase blood pressure in rats when it is injected into the cerebral ventricles. DHBMA also increases the affinity for dopamine D2 receptors which are linked to Parkinson's disease. This drug is used as a linker in the synthesis of prenylated synthons, which can be used to produce drugs with high affinity values and stereoisomers.

Formula: C₉H₁₁NO₂

Purity: Min. 95%

Color and Shape: Colorless Clear Liquid

Molecular weight: 165.19 g/mol

Ref: 3D-FD42203

2-(Aminomethyl)benzodioxan

CAS: 4442-59-5

Formula: C₉H₁₁NO₂

Purity: 98%

Color and Shape: Liquid

Molecular weight: 165.192

Ref: 10-F017482

2-Aminomethyl-1,4-benzodioxane

Controlled Product

CAS: 4442-59-5

Applications 2-Aminomethyl-1,4-benzodioxane is used in the synthesis of N-substituted (dihydrobenzodioxinyl)methylamine derivatives as D2 antagonists/5-HT1A partial agonists with potential as atypical antipsychotic agents in relation to affinity for α1 adrenoceptors.
References Birch, A. M., et al.: J. Med. Chem., 42, 3342 (1999);

Formula: C₉H₁₁NO₂

Color and Shape: Neat

Molecular weight: 165.19

Ref: TR-A615340