CAS 444904-63-6

2-Quinazolinamine, 5,6-dichloro-1,4-dihydro-

Description:

2-Quinazolinamine, 5,6-dichloro-1,4-dihydro- is a chemical compound characterized by its quinazoline structure, which consists of a fused benzene and pyrimidine ring. This compound features two chlorine substituents at the 5 and 6 positions of the quinazoline ring, contributing to its unique reactivity and potential biological activity. The presence of the amino group at the 2-position enhances its solubility in polar solvents and may influence its interaction with biological targets. As a dihydro derivative, it possesses a saturated bond in the ring, which can affect its stability and reactivity compared to fully aromatic compounds. This compound is of interest in medicinal chemistry due to its potential pharmacological properties, including anti-cancer and anti-inflammatory activities. Its specific characteristics, such as melting point, boiling point, and solubility, would depend on the molecular interactions and the environment in which it is studied. Overall, 2-Quinazolinamine, 5,6-dichloro-1,4-dihydro- represents a class of compounds that may offer valuable insights for drug development and therapeutic applications.

Formula: C₈H₇Cl₂N₃

Anagrelide Impurity 3

CAS: 444904-63-6

Formula: C₈H₇Cl₂N₃

Molecular weight: 216.07

Ref: 4Z-A-10309

Anagrelide Impurity 3-13C6

CAS: 444904-63-6

Formula: C₂₁₃C₆H₈Cl₂N₃

Molecular weight: 223.03

Ref: 4Z-A-10310

2-Amino-5,6-dichloro-3,4-dihydroquinazoline

Controlled Product

CAS: 444904-63-6

Applications 2-Amino-5,6-dichloro-3,4-dihydroquinazoline is a metabolite of Anagrelide (A637300), a phosphodiesterase inhibitor with antiplatelet activity. Used as an antithrombocythemic.
References Fleming, J.S., et al.: Thromb. Res., 15, 373 (1979); Seiler, S., et al.: J. Pharmacol. Exp. Ther., 243, 767 (1984); Silverstein, M. N., et al.: N. Engl. J. Med., 318, 1292 (1988); Spencer, C.M., et al.: Drugs, 47, 809 (1994)

Formula: C₈H₇Cl₂N₃

Color and Shape: Neat

Molecular weight: 216.07

Ref: TR-A604731

5,6-Dichloro-1,4-dihydro-2-quinazolinamine

CAS: 444904-63-6

5,6-Dichloro-1,4-dihydro-2-quinazolinamine (5,6-DCQ) is a small molecule that has been used in vitro to study postnatal development. 5,6-DCQ binds to magnesium and forms a cation complex. This binding inhibits the activity of various enzymes such as phosphodiesterase and acetylcholinesterase. 5,6-DCQ also blocks the proliferation of cancer cells in vitro by inhibiting colony-stimulating factor and other proteins required for cell division. 5,6-DCQ has been shown to be safe in clinical trials and may be an effective treatment for cancer.

Formula: C₈H₇Cl₂N₃

Purity: Min. 95%

Molecular weight: 216.07 g/mol

Ref: 3D-ID10269

RL-603

CAS: 444904-63-6

RL-603, a metabolite of Anagrelide, exhibits platelet-reducing activity in a mouse model.

Formula: C₈H₇Cl₂N₃

Color and Shape: Solid

Molecular weight: 216.07

Ref: TM-T88607

2-Amino-5,6-Dichloro-3,4-Dihydroquinazoline

CAS: 444904-63-6

Formula: C₈H₇Cl₂N₃

Molecular weight: 216.06

Ref: ST-EA-CP-A76010