CAS 445238-07-3

Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 7-(difluoromethyl)-5-(4-methoxyphenyl)-N-[4-[[(2-methoxyphenyl)amino]sulfonyl]phenyl]-

Description:

Pyrazolo[1,5-a]pyrimidine-3-carboxamide, with the CAS number 445238-07-3, is a synthetic organic compound characterized by its complex structure, which includes a pyrazolo-pyrimidine core. This compound features a carboxamide functional group, which contributes to its potential as a bioactive molecule. The presence of difluoromethyl and methoxyphenyl substituents enhances its chemical properties, potentially influencing its solubility, stability, and biological activity. The sulfonamide moiety in the structure may also play a crucial role in its interaction with biological targets, making it of interest in medicinal chemistry. Compounds of this type are often investigated for their pharmacological properties, including anti-inflammatory and anticancer activities. The specific arrangement of functional groups can significantly affect the compound's reactivity and interaction with enzymes or receptors. Overall, this compound exemplifies the complexity and diversity of synthetic organic molecules used in drug discovery and development.

Formula: C₂₈H₂₃F₂N₅O₅S

Synonyms:

• Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 7-(difluoromethyl)-5-(4-methoxyphenyl)-N-[4-[[(2-methoxyphenyl)amino]sulfonyl]phenyl]-

I194496

CAS: 445238-07-3

I194496 is an effective inhibitor of cystathionine γ-lyase (CSE) with an IC50 value of 0.79 mM. It inhibits the growth of human TNBC cells by dual targeting the PI3K/Akt and Ras/Raf/ERK pathways. Additionally, I194496 suppresses the metastasis of human TNBC cells by downregulating the Anxa2/STAT3 and VEGF/FAK/Paxillin signaling pathways.

Formula: C₂₈H₂₃F₂N₅O₅S

Color and Shape: Solid

Molecular weight: 579.58

Ref: TM-T201096