CAS 446-72-0

Genistein

Description:

Genistein is a naturally occurring isoflavone, primarily found in soybeans and other legumes. It belongs to the class of phytoestrogens, which are plant-derived compounds that can mimic estrogen in the body. Genistein has a molecular formula of C15H10O5 and a molecular weight of approximately 270.24 g/mol. This compound exhibits a variety of biological activities, including antioxidant, anti-inflammatory, and potential anticancer properties. Genistein is known to interact with estrogen receptors, which may influence cell growth and differentiation. Additionally, it has been studied for its potential role in reducing the risk of hormone-related cancers, such as breast and prostate cancer. Genistein is also recognized for its ability to modulate various signaling pathways, including those involved in cell cycle regulation and apoptosis. Its solubility is generally higher in organic solvents than in water, and it is often used in dietary supplements and functional foods due to its health-promoting properties. Overall, genistein is a compound of significant interest in both nutritional science and pharmacology.

Formula: C₁₅H₁₀O₅

InChI: InChI=1/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H

InChI key: InChIKey=TZBJGXHYKVUXJN-UHFFFAOYSA-N

SMILES: O=C1C=2C(OC=C1C3=CC=C(O)C=C3)=CC(O)=CC2O

Synonyms:

• 4',5,7-Trihydroxyisoflavone
• 4′,5,7-Trihydroxyisoflavone
• 5,7,4'-Trihydroxyisoflavone
• 5,7-Dihidroxi-3-(4-Hidroxifenil)-4-Benzopirona
• 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron
• 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone
• 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
• 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
• Baichanin A
• Bio 300
• Bonistein
• Climagen F
• Csu 1999
• Fw 635I-2
• GeniVida
• Genistein
• Genisteol
• Genisterin
• Genistin aglycone
• Isoflavone, 4',5,7-trihydroxy-
• Isoflavone, 4′,5,7-trihydroxy-
• Npi 031L
• Nsc 36586
• Prunetol
• Sipi 807-1
• Sophoricol
• 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-
• C.I. 75610
• Natural Genistein
• genistein(synthetic)
• Genistein98%,99%
• AKOS NCG1-0029
• GENISTEIN FROM SOYBEAN 98%(HPLC)
• 5,7-DIHYDROXY-3-(4-HYDROXY-PHENYL)-CHROMEN-4-ONE
• differenola
• 4’,5,7-trihydroxy-isoflavon
• GENISTEIN FROM GLYCINE MAX (SOYBEAN)

Genistein

CAS: 446-72-0

Formula: C₁₅H₁₀O₅

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 270.24

Ref: 3B-G0272

4',5,7-Trihydroxyisoflavone, 99+%

CAS: 446-72-0

Inhibitor of tyrosine protein kinase

Formula: C₁₅H₁₀O₅

Purity: 99+%

Color and Shape: Off-white to pale brown, Powder

Molecular weight: 270.24

Ref: 02-J63241

Genistein

CAS: 446-72-0

Genistein analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₁₅H₁₀O₅

Purity: (HPLC) ≥99%

Color and Shape: Powder

Molecular weight: 270.24

Ref: 11-1372S

Genistein

CAS: 446-72-0

Aromatic heterocyclic pesticides with oxygen hetero-atom(s) only, nesoi

Formula: C₁₅H₁₀O₅

Color and Shape: White Beige Brown Powder

Molecular weight: 270.05282

Ref: 45-1288816

4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-

CAS: 446-72-0

Formula: C₁₅H₁₀O₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 270.2369

Ref: IN-DA00I8G3

Genistein

CAS: 446-72-0

Formula: C₁₅H₁₀O₅

Purity: (HPLC) ≥ 98.0%

Color and Shape: White, off-white, light yellow or grey-beige powder

Molecular weight: 270.24

Ref: 7W-GP7710

Genistein

CAS: 446-72-0

Genistein

Purity: ≥98%

Molecular weight: 270.24g/mol

Ref: 54-BUP14853

Genistein

CAS: 446-72-0

Formula: C₁₅H₁₀O₅

Color and Shape: Neat

Molecular weight: 270.24

Ref: 04-C13999800

Genistein

Controlled Product

CAS: 446-72-0

Formula: C₁₅H₁₀O₅

Color and Shape: Neat

Molecular weight: 270.24

Ref: 86-MM0748.00

Genistein

CAS: 446-72-0

Genistein, the major phytoestrogen in soy, is linked to diminished female reproductive performance and to cancer chemoprevention and decreased adipose deposition; genistein-induces hypermethylation persisted into adulthood, decreases ectopic Agouti expression and protecting offspring from obesity, suggests that in utero dietary genistein affects gene expression and alters susceptibility to obesity in adulthood by permanently altering the epigenome.

Formula: C₁₅H₁₀O₅

Purity: 95%~99%

Color and Shape: Yellow powder

Molecular weight: 270.24

Ref: BP-BP0634

Genistein

CAS: 446-72-0

Formula: C₁₅H₁₀O₅

Molecular weight: 270.24

Ref: 4Z-G-033

Genistein

CAS: 446-72-0

Genistein

Purity: >98%

Color and Shape: Powder

Molecular weight: 270.24g/mol

Ref: 54-BIMB2006

Genistein

CAS: 446-72-0

Genistein (NPI 031L) is a natural soy isoflavone, a multi-targeted tyrosine kinase inhibitor. Genistein has antitumor effects. Cost effective and quality assured.

Formula: C₁₅H₁₀O₅

Purity: 98.22% - 99.64%

Color and Shape: Rectangular Or Six-Sided Rods From 60% Alcohol Dendritic Needles From Ether Solid

Molecular weight: 270.24

Ref: TM-T1737

Genistein

CAS: 446-72-0

Oxygen-heterocyclic compound

Formula: C₁₅H₁₀O₅

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 270.24

Ref: 5G-89199

Genistein

Controlled Product

CAS: 446-72-0

Stability Light Sensitive
Applications Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol
References Akiyama, T., et al.: J. Biol. Chem., 262, 5592 (1987), O'Dell, T.J., et al.: Nature, 353, 588 (1991), Aharonovits, O., et al.: Biochim Biophys. Acta, 1112, 181 (1992), Platanias, L.C., et al.: J. Biol. Chem., 267, 24053 (1992), Yoshida, H., et al.: Biochim. Biophys. Acta, 1137, 321 (1992), Uckun, F.M., et al.: Science, 267, 886 (1995), Merck Index 12th ed. 4395, Huang, R.Q.; Fang, M.J.; Dillon, G.H., Mol. Brain Res. 67: 177-183 (1999)

Formula: C₁₅H₁₀O₅

Color and Shape: Light Yellow

Molecular weight: 270.24

Ref: TR-G350000

Genistein

CAS: 446-72-0

Genistein is a naturally occurring isoflavone, which is derived primarily from soy products and other legumes. Its chemical structure allows it to mimic the function of 17-beta-estradiol, a form of estrogen, by binding to estrogen receptors. This selective binding primarily targets estrogen receptor beta, leading to a range of biological effects. Moreover, Genistein exhibits antioxidant properties by scavenging free radicals and inhibiting oxidative stress.

Formula: C₁₅H₁₀O₅

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 270.24 g/mol

Ref: 3D-FG09961

Genistein

CAS: 446-72-0

M01798 - Genistein

Formula: C₁₅H₁₀O₅

Purity: 97%

Color and Shape: Solid, Light yellow powder

Molecular weight: 270.24

Ref: 10-M01798