CAS 4465-65-0

(1R,4aS,12aS)-3-[amino(hydroxy)methylidene]-4a,6,7-trihydroxy-N,N,11-trimethyl-2,4,5-trioxo-1,2,3,4,4a,5,12,12a-octahydrotetracen-1-aminium

Description:

The chemical substance with the name "(1R,4aS,12aS)-3-[amino(hydroxy)methylidene]-4a,6,7-trihydroxy-N,N,11-trimethyl-2,4,5-trioxo-1,2,3,4,4a,5,12,12a-octahydrotetracen-1-aminium" and CAS number 4465-65-0 is a complex organic compound characterized by its intricate polycyclic structure and multiple functional groups. It features a tetracyclic framework with several hydroxyl (-OH) and amino (-NH2) groups, contributing to its potential solubility in polar solvents and biological activity. The presence of trioxo groups indicates a high degree of oxidation, which may influence its reactivity and stability. The specific stereochemistry, denoted by the R and S configurations, suggests that the compound may exhibit chiral properties, potentially affecting its interactions in biological systems. This compound may be of interest in medicinal chemistry due to its structural complexity and the presence of functional groups that could participate in various biochemical interactions. However, detailed studies would be necessary to fully understand its properties, reactivity, and potential applications.

Formula: C₂₂H₂₃N₂O₇

InChI: InChI=1/C22H22N2O7/c1-8-9-5-4-6-12(25)13(9)17(26)14-10(8)7-11-16(24(2)3)18(27)15(21(23)30)20(29)22(11,31)19(14)28/h4-6,11,16,25-26,30-31H,7,23H2,1-3H3/p+1/t11-,16+,22-/m0/s1

4-EPIANHYDROTETRACYCLINE HYDROCHLORIDE CRS

CAS: 4465-65-0

4-EPIANHYDROTETRACYCLINE HYDROCHLORIDE CRS

Formula: C₂₂H₂₃ClN₂O₇

Color and Shape: Orange. Powder.

Molecular weight: 462.8802

Ref: 41-E0400000

4-Epianhydrotetracycline Hydrochloride

CAS: 4465-65-0

Tetracyclines and their derivatives; salts thereof

Formula: C₂₂H₂₂N₂O₇·HCl

Color and Shape: Dark Yellow Brown Solid

Molecular weight: 426.1427

Ref: 45-1236506

4-Epianhydrotetracycline hydrochloride

CAS: 4465-65-0

EATC, a tetracycline byproduct, combats Pseudomonas to E. coli with MIC50s of 0.75-16 mg/L.

Formula: C₂₂H₂₃ClN₂O₇

Color and Shape: Solid

Molecular weight: 462.88

Ref: TM-T36599

4-Epianhydrotetracycline hydrochloride

Controlled Product

CAS: 4465-65-0

Formula: C₂₂H₂₂N₂O₇·ClH

Color and Shape: Neat

Molecular weight: 462.88

Ref: 04-C13174500

Tetracycline EP Impurity D HCl (Chlortetracycline EP Impurity I HCl , Lymecycline EP Impurity D HCl , 4-Epianhydrotetracycline HCl )

CAS: 4465-65-0

Formula: C₂₂H₂₂N₂O₇·HCl

Molecular weight: 426.43 36.46

Ref: 4Z-T-4035

4-Epianhydrotetracycline Hydrochloride Hydrate (>85%)

Controlled Product

CAS: 4465-65-0

Applications An antibiotic derived from Tetracycline. Studies have shown that this derivative can have a 250-fold higher toxicity depending on the system under study. This compound is a contaminant of emerging concern (CECs).
References Simmons, D., et al.: J. Pharm. Sci., 55, 1313 (1966), Paemen, L., et al.: Biochem. Pharmacol., 52, 105 (1996),

Formula: C₂₂H₂₂N₂O₇·HCl·H₂O

Purity: >85%

Color and Shape: Neat

Molecular weight: 462.88

Ref: TR-E578070

4-Epianhydrotetracycline hydrochloride

CAS: 4465-65-0

4-Epianhydrotetracycline hydrochloride is a chemically modified antibiotic derivative, originating from the structural transformation of tetracycline. It is derived through epimerization and dehydration processes, which alter the parent compound's structure.

Formula: C₂₂H₂₃ClN₂O₇

Purity: Min. 95%

Molecular weight: 462.9 g/mol

Ref: 3D-EAA46565

Tetracycline EP Impurity D

CAS: 4465-65-0

Formula: C₂₂H₂₂N₂O₇HCl

Molecular weight: 426.4 : 36.46

Ref: ST-EA-CP-T200006

4-Epianhydrotetracycline hydrochloride hydrate

CAS: 4465-65-0, 7518-17-4

4-Epianhydrotetracycline hydrochloride hydrate is a chemical compound that inhibits the activation of protein kinase C (PKC) and blocks the apoptosis pathway. It has been shown to induce apoptosis in prostate cancer cells and also inhibits the proliferation of human microvessel endothelial cells. 4-Epianhydrotetracycline hydrochloride hydrate is stable in both human serum and wastewater, which makes it an ideal drug for treating many types of cancers. It is also used in pharmaceutical drugs as a cytochalasin, which are used to treat angina pectoris by reducing oxygen uptake by erythrocytes, thereby inhibiting oxidative phosphorylation. 4-Epianhydrotetracycline hydrochloride hydrate prevents mitochondrial cytochrome c release, thus blocking the apoptotic pathway in cells. This chemical compound may act as a regulatory molecule that affects energy metabolism and epidermal growth factor (EGF)

Formula: C₂₂H₂₃ClN₂O₇

Purity: Min. 95%

Molecular weight: 462.88 g/mol

Ref: 3D-FE22716