CAS 446859-33-2

2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine

Description:

2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine is a complex organic compound characterized by its multi-ring structure, which includes a naphthyridine moiety and a pyrazole ring substituted with a pyridine group. This compound typically exhibits properties such as moderate to high solubility in organic solvents, depending on the specific functional groups present. It may display biological activity, making it of interest in medicinal chemistry, particularly in the development of pharmaceuticals. The presence of nitrogen atoms in its structure suggests potential for hydrogen bonding and coordination with metal ions, which can influence its reactivity and interaction with biological targets. Additionally, the methyl group on the pyridine ring can affect the compound's lipophilicity and overall pharmacokinetic properties. As with many heterocyclic compounds, its synthesis may involve multi-step reactions, and its stability can be influenced by environmental factors such as pH and temperature. Overall, this compound represents a class of molecules that are valuable in research and development within the fields of chemistry and pharmacology.

Formula: C₁₇H₁₃N₅

InChI: InChI=1/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)

SMILES: Cc1cccc(c2c(c[nH]n2)c2ccc3c(cccn3)n2)n1

Synonyms:

• 1,5-Naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-
• 1,5-naphthyridine, 2-[5-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-
• 2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine
• Repsox
• 2-[3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine

RepSox

CAS: 446859-33-2

Formula: C₁₇H₁₃N₅

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 287.33

Ref: 3B-R0224

RepSox

CAS: 446859-33-2

RepSox

Purity: 98%

Molecular weight: 287.32g/mol

Ref: 54-OR1024251

RepSox

CAS: 446859-33-2

RepSox

Purity: ≥98%

Molecular weight: 287.32g/mol

Ref: 54-BUP09192

RepSox

CAS: 446859-33-2

Formula: C₁₇H₁₃N₅

Molecular weight: 287.32

Ref: 7W-GL9188

RepSox

CAS: 446859-33-2

RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM).

Formula: C₁₇H₁₃N₅

Purity: 98.8% - 99.73%

Color and Shape: Solid

Molecular weight: 287.32

Ref: TM-T6337

RepSox

CAS: 446859-33-2

Selective inhibitor of the transforming growth factor beta receptor TGFβ1. RepSox can replace Sox, a transcriptional factor required for cell self-renewal, in reprogramming of adult cells to induced pluripotent stem cells (iPSCs). In the cloned interspecies embryos, RepSox induced expression of pluripotency regulatory genes Oct4 and Nanog, improved viability and developmental potential of embryos in the pre-implantation stage.

Formula: C₁₇H₁₃N₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 287.32 g/mol

Ref: 3D-FR44793

2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine

CAS: 446859-33-2

Formula: C₁₇H₁₃N₅

Purity: 98%

Molecular weight: 287.326

Ref: 10-F237399

Alk 5 Inhibitor II

CAS: 446859-33-2

Applications Alk 5 Inhibitor II is a selective ATP competitive inhibitor of transforming growth factor-β (TGFβ). A potential drug for the treatment of fibrosis and cancer.
References Ren, J. et al.: Eur. J. Med. Chem., 44, 4259 (2009)

Formula: C₁₇H₁₃N₅

Color and Shape: Neat

Molecular weight: 287.32

Ref: TR-A540250