CAS 448184-48-3

2-[2-Ethoxy-5-[(4-ethyl-4-oxido-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one

Description:

The chemical substance known as "2-[2-Ethoxy-5-[(4-ethyl-4-oxido-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one," with the CAS number 448184-48-3, is a complex organic compound characterized by its multi-functional structure. It features an imidazotriazine core, which is known for its potential biological activity, particularly in medicinal chemistry. The presence of an ethoxy group and a sulfonyl moiety suggests that the compound may exhibit solubility in organic solvents and could interact with biological targets through hydrogen bonding and other non-covalent interactions. The piperazine ring contributes to its pharmacological properties, potentially enhancing its ability to cross biological membranes. Additionally, the presence of various substituents, such as the ethyl and propyl groups, may influence its lipophilicity and overall biological activity. This compound may be of interest in drug development, particularly in the fields of oncology or infectious diseases, although specific biological activities would require empirical investigation.

Formula: C₂₃H₃₂N₆O₅S

InChI: InChI=1S/C23H32N6O5S/c1-5-8-20-24-16(4)21-23(30)25-22(26-28(20)21)18-15-17(9-10-19(18)34-7-3)35(32,33)27-11-13-29(31,6-2)14-12-27/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30)

InChI key: InChIKey=GXUGEZIHENHAGP-UHFFFAOYSA-N

SMILES: O(CC)C1=C(C=C(S(=O)(=O)N2CCN(CC)(=O)CC2)C=C1)C=3NN4C(C(=O)N3)=C(C)N=C4CCC

Synonyms:

• Imidazo[5,1-f][1,2,4]triazin-4(1H)-one, 2-[2-ethoxy-5-[(4-ethyl-4-oxido-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propyl-
• 2-[2-Ethoxy-5-[(4-ethyl-4-oxido-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one
• Piperazine, 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-, 4-oxide
• Vardena hydrochloride impurity D
• 4-((4-ethoxy-3-(5-methyl-4-oxo-7-propyl-1,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)phenyl)sulfonyl)-1-ethylpiperazine 1-oxide
• Vardenafil Impurity 9(Vardenafil N-Oxide)
• Vardenafil N-Oxide Impurity

Vardenafil Related Compound D (2-{2-Ethoxy-5-[(4-ethyl-4-oxidopiperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propyl-imidazo[5,1-f][1,2,4]triazin-4(3H)-one)

CAS: 448184-48-3

Sulfonamides, nesoi

Formula: C₂₃H₃₂N₆O₅S

Color and Shape: White Powder

Molecular weight: 504.21549

Ref: 45-1711064

Vardenafil USP Related Compound D (Vardenafil N-Oxide)

CAS: 448184-48-3

Formula: C₂₃H₃₂N₆O₅S

Color and Shape: White To Off-White Solid

Molecular weight: 504.61

Ref: 4Z-V-0522

Vardenafil N-oxide

CAS: 448184-48-3

Vardenafil N-oxide

Purity: 98%

Ref: 54-OR1039828

Vardenafil N-Oxide

Controlled Product

CAS: 448184-48-3

Formula: C₂₃H₃₂N₆O₅S

Color and Shape: Neat

Molecular weight: 504.60

Ref: 86-MM1569.03

Vardenafil N-Oxide

Controlled Product

CAS: 448184-48-3

Applications Vardenafil N-Oxide is an impurity compound of Vardenafil Hydrochloride. It is used in the treatment of erectile dysfunction. It also functions an inhibitor of phosphodiestrase type 5(PDE-5) enzyme.
References Reddy, V. V., et al.: Synth. Commun., 42, 3513 (2012)

Formula: C₂₃H₃₂N₆O₅S

Color and Shape: Neat

Molecular weight: 504.60

Ref: TR-V098010

Vardenafil N-oxide

CAS: 448184-48-3

Vardenafil N-oxide is a medicinal compound that is an analog of vardenafil, a drug used to treat erectile dysfunction. This compound has been identified as a potential anticancer agent due to its ability to inhibit the activity of certain kinases involved in tumor growth and survival. Vardenafil N-oxide has been shown to induce apoptosis (cell death) in cancer cells, particularly those of Chinese hamster ovary origin. Additionally, this compound has demonstrated inhibitory effects on the growth of human prostate cancer cells and has been found in the urine of patients undergoing treatment with cysteamine, a medication used for the treatment of cystinosis. Overall, Vardenafil N-oxide holds significant promise for the development of novel cancer therapies as an inhibitor of key signaling pathways involved in tumor progression.

Formula: C₂₃H₃₂N₆O₅S

Purity: Min. 95%

Molecular weight: 504.6 g/mol

Ref: 3D-YSA18448

Vardenafil USP Related Compound D

CAS: 448184-48-3

Formula: C₂₃H₃₂N₆O₅S

Molecular weight: 504.61

Ref: ST-EA-CP-V28019