CAS 448906-42-1

2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester

Description:

2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester, with the CAS number 448906-42-1, is a chemical compound characterized by its unique structural features that combine an indole moiety with a thiazolecarboxylic acid derivative. This compound typically exhibits a molecular structure that includes an indole ring, which is known for its aromatic properties and biological activity, and a thiazole ring that contributes to its potential reactivity and solubility characteristics. The presence of the methyl ester functional group suggests that it may have enhanced lipophilicity, which can influence its pharmacokinetic properties. Additionally, compounds of this nature may exhibit various biological activities, including antimicrobial or anticancer properties, making them of interest in medicinal chemistry. The compound's solubility, stability, and reactivity can vary based on environmental conditions such as pH and temperature, which are important considerations for its application in research and development. Overall, this compound represents a fascinating intersection of organic chemistry and potential therapeutic applications.

Formula: C₁₄H₁₀N₂O₃S

InChI: InChI=1S/C14H10N2O3S/c1-19-14(18)11-7-20-13(16-11)12(17)9-6-15-10-5-3-2-4-8(9)10/h2-7,15H,1H3

InChI key: InChIKey=KDDXOGDIPZSCTM-UHFFFAOYSA-N

SMILES: C(=O)(C=1C=2C(NC1)=CC=CC2)C3=NC(C(OC)=O)=CS3

Synonyms:

• 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester
• 2-(1′H-Indole-3′-carbonyl)thiazole-4-carboxylic acid methyl ester
• 4-Thiazolecarboxylic acid, 2-(1H-indol-3-ylcarbonyl)-, methyl ester
• Ari-001
• Methyl 2-(1H-indol-3-ylcarbonyl)-1,3-thiazole-4-carboxylate
• ITE

ITE

CAS: 448906-42-1

ITE

Purity: ≥95%

Molecular weight: 286.31g/mol

Ref: 54-BUP05783

ITE

CAS: 448906-42-1

Formula: C₁₄H₁₀N₂O₃S

Purity: >95.0%(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 286.31

Ref: 3B-I1292

ITE

CAS: 448906-42-1

ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) (Ki : 3 nM), has immunosuppressive activity.

Formula: C₁₄H₁₀N₂O₃S

Purity: 97.91% - 99.14%

Color and Shape: Solid

Molecular weight: 286.31

Ref: TM-T7202

ITE

CAS: 448906-42-1

Endogenous non-toxic agonist of the aryl hydrocarbon receptor (AhR) with immunosuppressive activity. The compound also inhibits the nuclear translocation of Smad2/3/4 leading to aberrant Transforming Growth Factor-β1 (TGFβ1) signaling. It inhibits myofibroblast differentiation and is a potential anti-scarring agent.

Formula: C₁₄H₁₀N₂O₃S

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 286.31 g/mol

Ref: 3D-BI166811

ITE - Bio-X ™

CAS: 448906-42-1

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₁₄H₁₀N₂O₃S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 286.31 g/mol

Ref: 3D-BI300012

ITE

Controlled Product

CAS: 448906-42-1

Applications ITE is an endogenous AHR ligand that parenterally or orally induces FoxP3+ Treg that suppress exprimental autoimmune encephalomyelitis. ITE promotes the induction of active immunology tolerance and identifies nontoxic endogenous AHR ligands.
References Quintana, F., et al.: Proc. Natl. Acad. Sci. USA, 107, 20768 (2010);

Formula: C₁₄H₁₀N₂O₃S

Color and Shape: Neat

Molecular weight: 286.31

Ref: TR-I942030