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CAS 4528-51-2

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(+)-Selegiline

Description:
(+)-Selegiline, also known as L-deprenyl, is a selective monoamine oxidase B (MAO-B) inhibitor primarily used in the treatment of Parkinson's disease and major depressive disorder. It is characterized by its ability to enhance dopaminergic activity in the brain, which is beneficial for patients with Parkinson's disease. The compound has a chiral center, resulting in its enantiomeric form, which is biologically active. (+)-Selegiline is typically administered in its hydrochloride salt form, which is a white to off-white crystalline powder. It is soluble in organic solvents like ethanol and methanol but has limited solubility in water. The substance exhibits a relatively low toxicity profile, but it can interact with certain medications and dietary tyramine, necessitating caution in its use. Additionally, (+)-Selegiline has been studied for its potential neuroprotective effects and may have implications in age-related cognitive decline. Its pharmacokinetics involve rapid absorption and metabolism, with a half-life that allows for once-daily dosing in therapeutic applications.
Formula:C13H17N
InChI:InChI=1S/C13H17N/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13/h1,5-9,12H,10-11H2,2-3H3/t12-/m0/s1
InChI key:InChIKey=MEZLKOACVSPNER-LBPRGKRZSA-N
SMILES:C([C@@H](N(CC#C)C)C)C1=CC=CC=C1
Synonyms:
  • Benzeneethanamine, N,α-dimethyl-N-2-propyn-1-yl-, (αS)-
  • (αS)-N,α-Dimethyl-N-2-propyn-1-ylbenzeneethanamine
  • Phenethylamine, N,α-dimethyl-N-2-propynyl-, D-(+)-
  • Benzeneethanamine, N,α-dimethyl-N-2-propynyl-, (S)-
  • Benzeneethanamine, N,α-dimethyl-N-2-propynyl-, (αS)-
  • Phenethylamine, N,a-dimethyl-N-2-propynyl-, D-(+)- (8CI)
  • (αS)-N,α-Dimethyl-N-(2-propynyl)benzeneethanamine
  • Selegiline hydrochloride EP Impurity E
  • S(+)-DEPRENYL HCL
  • (S)-Selegiline
  • See more synonyms
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