CAS 4530-20-5

N-(tert-Butoxycarbonyl)glycine

Description:

N-(tert-Butoxycarbonyl)glycine, commonly referred to as Boc-glycine, is an amino acid derivative characterized by the presence of a tert-butoxycarbonyl (Boc) protecting group attached to the amino group of glycine. This compound is typically a white to off-white solid and is soluble in polar organic solvents such as methanol and dimethyl sulfoxide (DMSO), but less soluble in non-polar solvents. The Boc group serves as a protective moiety that stabilizes the amino group during peptide synthesis, allowing for selective reactions without interfering with the amino functionality. Boc-glycine is widely used in organic synthesis, particularly in the preparation of peptides and other complex molecules. Its stability under various reaction conditions makes it a valuable intermediate in pharmaceutical and biochemical applications. Additionally, it can be deprotected under mild acidic conditions, regenerating the free amino group for further reactions. Overall, Boc-glycine is an essential compound in the field of synthetic organic chemistry and peptide synthesis.

Formula: C₇H₁₃NO₄

InChI: InChI=1S/C7H13NO4/c1-7(2,3)12-6(11)8-4-5(9)10/h4H2,1-3H3,(H,8,11)(H,9,10)

InChI key: InChIKey=VRPJIFMKZZEXLR-UHFFFAOYSA-N

SMILES: O(C(NCC(O)=O)=O)C(C)(C)C

Synonyms:

• (tert-Butoxycarbonyl)aminoacetic acid
• (tert-Butoxycarbonyl)glycine
• 2-(tert-Butoxycarbonylamino)acetic acid
• 2-[(2-Methylpropan-2-yl)oxycarbonylamino]acetic acid
• Boc-<span class="text-smallcaps">L</span>-glycine
• Boc-Gly-OH
• Boc-Gly-OH~N-(tert-Butoxycarbonyl)glycine
• Glycine, N-[(1,1-dimethylethoxy)carbonyl]-
• Glycine, N-carboxy-, N-tert-butyl ester
• N-(terc-butoxicarbonil)glicina
• N-(tert-Butoxycarbonyl)glycin
• N-(tert-Butoxycarbonyl)glycine
• N-Boc-glycine
• N-[(1,1-Dimethylethoxy)carbonyl]glycine
• N-[(tert-Butyloxy)carbonyl]glycine
• N-[[(1,1-Dimethylethyl)oxy]carbonyl]glycine
• N-t-Butyloxycarbonylglycine
• N-tert-Butoxycarbonyl-2-aminoacetic acid
• N-tert-Butoxycarbonylglycine
• N^α-tert-Butyloxycarbonylglycine
• Nsc 127669
• NtertButoxycarbonylglycine
• Nα-tert-Butyloxycarbonylglycine
• [(Tert-Butoxycarbonyl)Amino]Acetate
• t-Butyloxycarbonylglycine

N-(tert-Butoxycarbonyl)glycine

CAS: 4530-20-5

Formula: C₇H₁₃NO₄

Purity: >98.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 175.18

Ref: 3B-B1185

N-Boc-glycine, 98+%

CAS: 4530-20-5

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₇H₁₃NO₄

Purity: 98+%

Color and Shape: Crystals or powder or crystalline powder, White

Molecular weight: 175.18

Ref: 02-A11579

Boc-Gly-OH

CAS: 4530-20-5

M03287 - Boc-Gly-OH

Formula: C₇H₁₃NO₄

Purity: 97%

Color and Shape: Solid, Powder or Crystalline Powder

Molecular weight: 175.184

Ref: 10-M03287

Boc-Gly-OH

CAS: 4530-20-5

Bachem ID: 4001229.

Formula: C₇H₁₃NO₄

Purity: > 99%

Color and Shape: White

Molecular weight: 175.19

Ref: 01-4001229

Boc-Glycine

CAS: 4530-20-5

Formula: C₇H₁₃NO₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 175.1824

Ref: IN-DA0034JU

[(t-Butoxycarbonyl)amino]acetic acid

CAS: 4530-20-5

[(t-Butoxycarbonyl)amino]acetic acid

Formula: C₇H₁₃NO₄

Purity: 97%

Color and Shape: white solid

Molecular weight: 175.18241g/mol

Ref: 54-OR323299

Boc-Gly-OH

CAS: 4530-20-5

Formula: (CH₃)₃COCONHCH₂CO₂H

Molecular weight: 175.18

Ref: 7W-GM7526

BOC-Glycine extrapure, 99%

CAS: 4530-20-5

Formula: C₇H₁₃NO₄

Purity: min. 99%

Color and Shape: White, Crystalline powder

Molecular weight: 175.20

Ref: SR-71943

N-Boc-glycine

Controlled Product

CAS: 4530-20-5

Applications Used in the composition of drugs containing Ketoprofen, and Sodium hyaluronate as antiinflammatory agents.
References Bajusz, S., et al.: J. Med. Chem., 33, 1729 (1990), Dahlgren, A., et al.: Bioorg. Med. Chem., 10, 1829 (2002),

Formula: C₇H₁₃NO₄

Color and Shape: Neat

Molecular weight: 175.18

Ref: TR-B656125

N-Boc-glycine

CAS: 4530-20-5

N-Boc-glycine is a chemical compound used in the synthesis of cyclic peptides. N-Boc-glycine is synthesized by the reaction of glycine with methanol and hydrochloric acid in the presence of an activated form of carbon monoxide. The pharmacokinetic properties of N-Boc-glycine are similar to those for human immunoglobulin, and it can be used as a reference compound for preparative high performance liquid chromatography (HPLC). It has been shown that the nitrogen atoms in N-Boc-glycine are chemically stable, which makes it suitable for asymmetric synthesis. N-Boc-glycine also has potent antagonist effects on biochemical properties such as calcium channel blockade, inhibition of platelet aggregation, and inhibition of neutrophil chemotaxis.

Formula: C₇H₁₃NO₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 175.18 g/mol

Ref: 3D-FB18945

Boc-Gly-OH

CAS: 4530-20-5

Boc-Gly-OH is a cyclic peptide with a fatty acid acyl chain. It is synthesized by reacting the amino acid glycine with sodium carbonate in the presence of trifluoroacetic acid to form the intermediate Boc-Gly-OSu. The product is then reacted with allyl bromide in a second step to produce Boc-Gly-OCH2CH2Br and then reacted with calcium chloride to yield the final product. Boc-Gly-OH has been used as an HIV inhibitor, which may be due to its ability to bind to both CD4 and gp120 proteins on the surface of HIV. This binding inhibits viral entry into host cells by blocking protease activity and fusion of viral envelope with host cell membrane, leading to inhibition of HIV infection.

Formula: C₇H₁₃NO₄

Purity: Min. 95%

Molecular weight: 175.18 g/mol

Ref: 3D-BLG-2054