CAS 4542-23-8

Succinoadenosine

Description:

Succinoadenosine, with the CAS number 4542-23-8, is a nucleotide derivative that plays a role in various biochemical processes. It is characterized by the presence of an adenosine moiety linked to a succinic acid group. This compound is typically involved in cellular signaling and energy transfer, similar to other adenosine derivatives. Its structure features a purine base (adenine) attached to a ribose sugar, which is further connected to a succinyl group. The presence of the succinyl group can influence the compound's solubility, stability, and interaction with biological targets. Succinoadenosine may also participate in metabolic pathways and has potential implications in pharmacology and biochemistry, particularly in studies related to energy metabolism and cellular signaling mechanisms. As with many nucleotides, it may exhibit various biological activities, including modulation of enzyme activity and involvement in cellular communication. Further research is often necessary to fully elucidate its specific roles and applications in biological systems.

Formula: C₁₄H₁₇N₅O₈

InChI: InChI=1S/C14H17N5O8/c20-2-6-9(23)10(24)13(27-6)19-4-17-8-11(15-3-16-12(8)19)18-5(14(25)26)1-7(21)22/h3-6,9-10,13,20,23-24H,1-2H2,(H,21,22)(H,25,26)(H,15,16,18)/t5-,6+,9+,10+,13+/m0/s1

InChI key: InChIKey=VKGZCEJTCKHMRL-VWJPMABRSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N[C@@H](CC(O)=O)C(O)=O)N=CN3)O[C@H](CO)[C@H]1O

Synonyms:

• (2S)-2-({9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-9H-purin-6-yl}amino)butanedioic acid (non-preferred name)
• 4542-23-8
• 6-(1,2-Dicarboxyethylamino)-9-β-<span class="text-smallcaps">D</span>-ribofuranosylpurine
• <span class="text-smallcaps">L</smallcap>-Aspartic acid, N-(9-β-<smallcap>D</span>-ribofuranosyl-9H-purin-6-yl)-
• Adenosine, N-(1,2-dicarboxyethyl)-, (S)-
• Aspartic acid, N-(9-β-<span class="text-smallcaps">D</smallcap>-ribofuranosyl-9H-purin-6-yl)-, <smallcap>L</span>-
• Aspartic acid, N-9-ribofuranosyl-9H-purin-6-yl-
• N-(9-b-D-ribofuranosyl-9H-purin-6-yl)-L-Aspartic acid
• N-(9-β-<span class="text-smallcaps">D</smallcap>-Ribofuranosyl-9H-purin-6-yl)-<smallcap>L</span>-aspartic acid
• N⁶-Succinyloadenosine
• Succinoadenosine
• Aspartic acid, N-(9-β-D-ribofuranosyl-9H-purin-6-yl)-, L-

N6-Succinyl adenosine

CAS: 4542-23-8

Formula: C₁₄H₁₇N₅O₈

Purity: ≥ 96.0% (anhydrous basis)

Color and Shape: White to off-white powder

Molecular weight: 383.31

Ref: 7W-GN4609

N6-Succinyl Adenosine-D3

Controlled Product

CAS: 4542-23-8

Applications A deuterated isotope of N6-Succinyl Adenosine (S688825). Succinyladenosine (S-Ado) is a biochemical marker of adenylosuccinase deficiency - the genetic defect of purine de novo synthesis.
References Wevers, R., et al.: Clin. Chem., 41, 744 (1995), Nassogne, M., et al.: Brain Dev., 22, 383 (2000),

Formula: C₁₄D₃H₁₄N₅O₈

Color and Shape: Off White

Molecular weight: 386.332

Ref: TR-S688826

N6-Succinyl Adenosine

CAS: 4542-23-8

Applications Succinyladenosine (S-Ado) is a biochemical marker of adenylosuccinase deficiency - the genetic defect of purine de novo synthesis.  S-Ado has been previously reported as normally undetectable in cerebrospinal fluid (CSF) of children not suffering from this defect.
References Wevers, R., et al.: Clin. Chem., 41, 744 (1995), Nassogne, M., et al.: Brain Dev., 22, 383 (2000), Jurecka, A., et al.: Mol. Genet., 94, 435 (2008),

Formula: C₁₄H₁₇N₅O₈

Color and Shape: White To Light Yellow

Molecular weight: 383.31

Ref: TR-S688825

N6-Succinyl adenosine

CAS: 4542-23-8

N6-Succinyl adenosine is a biochemical that is involved in the transfer of fatty acids across membranes. It has been shown to be effective in transfection experiments, where it can be used to increase the expression of genes. N6-Succinyl adenosine has also been shown to be an important substrate for various dehydrogenases. Deficiency of these enzymes leads to orotic aciduria, which is characterized by elevated levels of orotic acid in blood and urine and may lead to mental retardation. A linear calibration curve was generated for diagnosis purposes, with the enzyme activities being determined using a logistic regression model.

Formula: C₁₄H₁₇N₅O₈

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 383.31 g/mol

Ref: 3D-NS16562

Succinyladenosine

CAS: 4542-23-8

Succinyladenosine, a marker for ASL deficiency, is made by dephosphorylating S-AMP with 5-nucleotidase.

Formula: C₁₄H₁₇N₅O₈

Color and Shape: Solid

Molecular weight: 383.317

Ref: TM-T37977