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CAS 455955-27-8

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2-Chloro-5-fluoroquinoline

Description:
2-Chloro-5-fluoroquinoline is a heterocyclic organic compound that belongs to the quinoline family, characterized by a bicyclic structure containing a fused benzene and pyridine ring. This compound features a chlorine atom at the second position and a fluorine atom at the fifth position of the quinoline ring, which can influence its chemical reactivity and biological activity. It is typically a pale yellow to off-white solid and is sparingly soluble in water but more soluble in organic solvents. The presence of halogen substituents often enhances the compound's lipophilicity, potentially affecting its pharmacokinetic properties. 2-Chloro-5-fluoroquinoline may exhibit antimicrobial or antitumor activities, making it of interest in medicinal chemistry. Its synthesis usually involves halogenation reactions and can be achieved through various methods, including electrophilic aromatic substitution. As with many halogenated compounds, it is essential to handle it with care due to potential toxicity and environmental concerns.
Formula:C9H5ClFN
InChI:InChI=1S/C9H5ClFN/c10-9-5-4-6-7(11)2-1-3-8(6)12-9/h1-5H
InChI key:InChIKey=QGVJVNBPDLHVHV-UHFFFAOYSA-N
SMILES:FC=1C2=C(N=C(Cl)C=C2)C=CC1
Synonyms:
  • Quinoline, 2-chloro-5-fluoro-
  • 2-Chloro-5-fluoroquinoline
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