CAS 459856-18-9

Pexacerfont

Description:

Pexacerfont, identified by its CAS number 459856-18-9, is a chemical compound that functions primarily as a selective antagonist of the corticotropin-releasing factor (CRF) receptor. This compound is of interest in pharmacological research, particularly in the context of anxiety and stress-related disorders, as it may help modulate the body's response to stress by inhibiting the action of CRF, a key hormone involved in the stress response. Pexacerfont is characterized by its specific binding affinity to CRF receptors, which distinguishes it from other compounds that may have broader or non-selective effects. Its chemical structure includes various functional groups that contribute to its biological activity and pharmacokinetic properties. Research into Pexacerfont has explored its potential therapeutic applications, side effects, and overall efficacy in clinical settings. As with many investigational drugs, ongoing studies are essential to fully understand its safety profile and therapeutic potential.

Formula: C₁₈H₂₄N₆O

InChI: InChI=1S/C18H24N6O/c1-7-10(2)19-18-22-13(5)21-17-16(12(4)23-24(17)18)14-8-9-15(25-6)20-11(14)3/h8-10H,7H2,1-6H3,(H,19,21,22)/t10-/m1/s1

InChI key: InChIKey=LBWQSAZEYIZZCE-SNVBAGLBSA-N

SMILES: CC=1C(=C2N(C(N[C@@H](CC)C)=NC(C)=N2)N1)C3=C(C)N=C(OC)C=C3

Synonyms:

• BMS 562086
• 8-(6-Methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo[1,5-a]-1,3,5-triazin-4-amine
• Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-(6-methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]-
• Pexacerfont

8-(6-Methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo[1,5-a]-1,3,5-triazin-4-amine

CAS: 459856-18-9

Formula: C₁₈H₂₄N₆O

Purity: 99%

Color and Shape: Solid

Molecular weight: 340.4228

Ref: IN-DA00DJPD

N-((R)-sec-Butyl)-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine

CAS: 459856-18-9

N-((R)-sec-Butyl)-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine

Purity: 99%

Molecular weight: 340.43g/mol

Ref: 54-OR1066722

Pexacerfont

CAS: 459856-18-9

Pexacerfont is an experimental drug that has been used as a model to study the pharmacokinetic properties of drugs. It has been shown to be an antagonist of gamma-aminobutyric acid (GABA), and this may be due to its ability to inhibit the binding of GABA to its receptors. Pexacerfont has also been shown to have pharmacological effects in humans, such as improving locomotor activity and reducing symptoms of anxiety. Pexacerfont is not toxic in animal studies, but it is unclear if these results are clinically relevant.

Formula: C₁₈H₂₄N₆O

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 340.42 g/mol

Ref: 3D-FP170137

Pexacerfont

CAS: 459856-18-9

Pexacerfont (BMS-562086) is a selective antagonist of the corticotropin-releasing factor receptor (IC50: 6.1±0.6 nM for the human CRF1 receptor).

Formula: C₁₈H₂₄N₆O

Purity: 99.77%

Color and Shape: Solid

Molecular weight: 340.42

Ref: TM-T16475