CAS 459868-92-9

Rucaparib phosphate

Description:

Rucaparib phosphate is a small molecule inhibitor primarily used in cancer therapy, particularly for treating certain types of ovarian and breast cancers associated with BRCA mutations. It functions as a poly(ADP-ribose) polymerase (PARP) inhibitor, which interferes with the DNA repair mechanisms in cancer cells, leading to cell death. The compound is characterized by its ability to selectively target cancer cells with defective DNA repair pathways, making it a valuable option in precision medicine. Rucaparib phosphate is typically administered orally and has been studied for its efficacy in both monotherapy and combination therapy settings. Its pharmacokinetics include absorption, distribution, metabolism, and excretion profiles that are crucial for determining dosing regimens. Common side effects may include fatigue, nausea, and hematological changes, which are important considerations in patient management. Overall, Rucaparib phosphate represents a significant advancement in targeted cancer therapies, offering hope for improved outcomes in patients with specific genetic backgrounds.

Formula: C₁₉H₂₁FN₃O₅P

InChI: InChI=1/C19H18FN3O.H3O4P/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15;1-5(2,3)4/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24);(H3,1,2,3,4)

SMILES: CNCc1ccc(cc1)c1c2CCNC(=O)c3cc(cc(c23)[nH]1)F.OP(=O)(O)O

Synonyms:

• Ag-14699
• AG-014447 (as free base)
• 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one phosphate
• Pf-01367338
• Ag-014699
• 8-Fluoro-2-[4-(methylaminomethyl)phenyl]-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-6-one phosphate

Ag-014699

CAS: 459868-92-9

Formula: C₁₉H₂₁FN₃O₅P

Purity: 99%

Color and Shape: Solid

Molecular weight: 421.3593

Ref: IN-DA00DAAB

Rucaparib

CAS: 459868-92-9

Formula: C₁₉H₁₈FN₃O

Molecular weight: 323.36

Ref: 7W-GP0727

8-Fluoro-2-(4-((Methylamino)Methyl)Phenyl)-4,5-Dihydro-1H-Azepino[5,4,3-Cd]Indol-6(3H)-One Phosphate

CAS: 459868-92-9

8-Fluoro-2-(4-((Methylamino)Methyl)Phenyl)-4,5-Dihydro-1H-Azepino[5,4,3-Cd]Indol-6(3H)-One Phosphate

Purity: 99%

Molecular weight: 421.36g/mol

Ref: 54-PC108652

Rucaparib Phosphate

CAS: 459868-92-9

Formula: C₁₉H₁₈FN₃O·H₃O₄P

Molecular weight: 323.37 97.99

Ref: 4Z-R-153010

Rucaparib Phosphate

CAS: 459868-92-9

Rucaparib Phosphate

Purity: ≥98%

Molecular weight: 421.36g/mol

Ref: 54-BUP08477

Rucaparib Phosphate

CAS: 459868-92-9

Rucaparib Phosphate (PF-01367338 phosphate) is an inhibitor of PARP that is used in clinical therapy to sensitize cancer cells to chemotherapy.

Formula: C₁₉H₁₈FN₃O·H₃PO₄

Purity: 99.37%

Color and Shape: Solid

Molecular weight: 421.36

Ref: TM-T6127

Rucaparib phosphate

Controlled Product

CAS: 459868-92-9

Inhibitor of poly (ADP-ribose) polymerase enzyme; antineoplastic

Purity: Min. 95%

Ref: 3D-FF141806