CAS 460085-45-4

[(2R,3S,4R,5S)-4,5-dihydroxy-6-(hydroxymethyl)-2-(4-methyl-2-oxo-chromen-7-yl)oxy-tetrahydropyran-3-yl]sulfamoyloxysodium

Description:

The chemical substance with the name "[(2R,3S,4R,5S)-4,5-dihydroxy-6-(hydroxymethyl)-2-(4-methyl-2-oxo-chromen-7-yl)oxy-tetrahydropyran-3-yl]sulfamoyloxysodium" and CAS number "460085-45-4" is a complex organic compound characterized by its unique structural features. It contains a tetrahydropyran ring, which is a six-membered cyclic ether, and multiple hydroxyl groups that contribute to its hydrophilicity and potential biological activity. The presence of a sulfamoyl group suggests that it may exhibit properties typical of sulfonamide compounds, which are known for their antibacterial activity. Additionally, the incorporation of a chromen-7-yl moiety indicates potential interactions with biological targets, possibly influencing its pharmacological profile. The sodium salt form implies enhanced solubility in aqueous environments, which is advantageous for biological applications. Overall, this compound's intricate structure and functional groups suggest it may have significant implications in medicinal chemistry, particularly in the development of therapeutic agents.

Formula: C₁₆H₁₈NNaO₁₀S

InChI: InChI=1/C16H19NO10S.Na/c1-7-4-12(19)26-10-5-8(2-3-9(7)10)25-16-13(17-28(22,23)24)15(21)14(20)11(6-18)27-16;/h2-5,11,13-18,20-21H,6H2,1H3,(H,22,23,24);/q;+1/p-1/t11?,13-,14+,15+,16-;/m0./s1/rC16H18NNaO10S/c1-7-4-12(20)26-10-5-8(2-3-9(7)10)25-16-13(17-29(23,24)28-18)15(22)14(21)11(6-19)27-16/h2-5,11,13-17,19,21-22H,6H2,1H3/t11?,13-,14+,15+,16-/m0/s1

SMILES: Cc1cc(=O)oc2cc(ccc12)OC1C(C(C(C(CO)O1)O)O)NS(=O)(=O)O.[Na]

4-Methylumbelliferyl 2-deoxy-2-sulfamino-α-D-glucopyranoside sodium salt

CAS: 460085-45-4

4-Methylumbelliferyl 2-deoxy-2-sulfamino-α-D-glucopyranoside sodium salt

Purity: 97%

Molecular weight: 439.37g/mol

Ref: 54-OR1054400

4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside (sodium salt)

CAS: 460085-45-4

4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside (4-MU-α-GlcNS) is a fluorogenic substrate of heparin sulphamidase.

Formula: C₁₆H₁₈NNaO₁₀S

Color and Shape: Solid

Molecular weight: 439.37

Ref: TM-T37568

4-Methylumbelliferyl 2-deoxy-2-sulfamino-a-D-glucopyranoside sodium salt

CAS: 460085-45-4

Formula: C₁₆H₁₈NO₁₀SNa

Purity: ≥ 98.0%

Color and Shape: White to off-white powder or solid

Molecular weight: 439.37

Ref: 7W-GC8529

4-Methylumbelliferyl 2-Sulfamino-2-deoxy-α-D-glucopyranoside Sodium Salt

CAS: 460085-45-4

Stability Hygroscopic
Applications 4-Methylumbelliferyl 2-Sulfamino-2-deoxy-α-D-glucopyranoside Sodium Salt is a substrate for the lysosomal heparin sulphamidase. It is a fluorometric enzyme assay for the diagnosis of Sanfilippo disease type A (MPS IIIA). It is also a fluorogenic substrate for sulfamidase.
References Karpova, E.A., et al.: J. Inher. Metab. Dis., 19, 278 (1996), Dasgupta, F., et al.: Carbohydrate Res., 337, 1055 (2002),

Formula: C₁₆H₁₈NO₁₀S·Na

Color and Shape: White To Off-White

Molecular weight: 439.37

Ref: TR-M334851

4-Methylumbelliferyl 2-deoxy-2-sulfamino-a-D-glucopyranoside sodium salt - Moscerdam™ biochemical purity

CAS: 460085-45-4

4-Methylumbelliferyl 2-deoxy-2-sulfamino-a-D-glucopyranoside sodium salt (M3A or MU-GlcNS) is a fluorogenic substrate of heparin sulfamidase, used in the diagnosis of Mucopolysaccharidosis III type A (MPS III A). MPS III A, also known as Sanfilippo syndrome type A, is caused by the deficiency of heparan N-sulfatase. Heparin sulfamidase in the assay desulfates MU-GlcNS to 4-methylumbelliferyl 2-amino-2-deoxy-α-D-glucopyranoside (MU-GlcNH2). To release fluorometrically measurable 4-methylumbelliferone (MU) and by-product glucosamine, MU-GlcNH2 is further hydrolysed by an enzyme such as yeast α-glucosidase during a second incubation.

Formula: C₁₆H₁₈NO₁₀SNa

Purity: Min. 95 Area-%

Color and Shape: White Powder

Molecular weight: 439.37 g/mol

Ref: 3D-EM06602