CAS 461054-93-3

(3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester

Description:

The chemical substance with the name "(3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester" and CAS number "461054-93-3" is a complex organic compound characterized by its multi-cyclic structure, which includes a pyrazino-pyridoindole framework. This compound features multiple stereocenters, indicating chirality, which can influence its biological activity and interactions. The presence of a methoxy group and a branched alkyl chain (2-methylpropyl) suggests potential lipophilicity, which may affect its solubility and permeability in biological systems. The dioxopyrazine moiety indicates potential reactivity and interaction with various biological targets. Additionally, the ester functional group implies that the compound may undergo hydrolysis, leading to the release of the corresponding acid. Overall, this substance may exhibit unique pharmacological properties, making it of interest in medicinal chemistry and drug development, although specific biological activities would require empirical investigation.

Formula: C₂₆H₃₅N₃O₅

InChI: InChI=1/C26H35N3O5/c1-14(2)11-20-23-17(16-8-7-15(33-6)12-19(16)27-23)13-21-24(31)28-18(25(32)29(20)21)9-10-22(30)34-26(3,4)5/h7-8,12,14,18,20-21,27H,9-11,13H2,1-6H3,(H,28,31)/t18-,20-,21-/m0/s1

Synonyms:

• Pyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid, 1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxo-, 1,1-dimethylethyl ester, (3S,6S,12aS)-
• tert-Butyl 3-[(3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl]propanoate
• tert-butyl 3-[(3S,6S,12aS)-9-methoxy-6-(2-methylpropyl)-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl]propanoate

Ko143 Hydrate

CAS: 461054-93-3

Ko143 Hydrate

Purity: 99+%

Ref: 54-OR1023857

Ko 143

CAS: 461054-93-3

Ko 143

Purity: ≥98%

Molecular weight: 469.57g/mol

Ref: 54-BUP05926

Ko143 hydrate

CAS: 461054-93-3

Formula: C₂₆H₃₅N₃O₅·xH₂O

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 469.57 (anhydrous)

Ref: 7W-GL0099

Ko 143

CAS: 461054-93-3

Ko 143 is a selective inhibitor of ATP-binding cassette sub-family G member 2 (ABCG2; BCRP).

Formula: C₂₆H₃₅N₃O₅

Purity: 99.01% - 99.89%

Color and Shape: Solid

Molecular weight: 469.57

Ref: TM-TQ0186

KO 143

Controlled Product

CAS: 461054-93-3

Formula: C₂₆H₃₅N₃O₅

Color and Shape: Neat

Molecular weight: 469.573

Ref: TR-K655000

KO 143

CAS: 461054-93-3

KO 143 is a methyltransferase inhibitor that blocks the activity of p-glycoprotein. It has been shown to inhibit the activity of ABCG2 in vitro and is used for the treatment of cancer. KO 143 also inhibits protein kinase B (Akt), which is found in high levels in many types of cancer cells. KO 143 can be used synergistically with natural compounds, such as curcuminoids, to inhibit the growth of cancer cells.

Formula: C₂₆H₃₅N₃O₅

Purity: Min. 95%

Molecular weight: 469.57 g/mol

Ref: 3D-LTA05493