CAS 461432-26-8

Dapagliflozin

Description:

Dapagliflozin is a medication primarily used in the management of type 2 diabetes mellitus. It belongs to the class of drugs known as sodium-glucose co-transporter 2 (SGLT2) inhibitors, which work by preventing the reabsorption of glucose in the kidneys, thereby promoting its excretion in urine and lowering blood glucose levels. The chemical formula of dapagliflozin is C21H25ClO6S, and it features a sulfonyl group, a chlorophenyl moiety, and a glucose-like structure that facilitates its mechanism of action. Dapagliflozin is typically administered orally and is often prescribed in conjunction with other antidiabetic agents to enhance glycemic control. In addition to its glucose-lowering effects, it has been associated with weight loss and a reduction in blood pressure. Common side effects may include urinary tract infections and genital mycotic infections due to increased glucose in the urine. Overall, dapagliflozin represents a significant advancement in diabetes treatment, offering a unique approach to managing blood sugar levels.

Formula: C₂₁H₂₅ClO₆

InChI: InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1

InChI key: InChIKey=JVHXJTBJCFBINQ-ADAARDCZSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@@H](O)[C@@H]1O)C2=CC(CC3=CC=C(OCC)C=C3)=C(Cl)C=C2

Synonyms:

• (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-<span class="text-smallcaps">D</span>-glucitol
• (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol
• (1S)-1,5-anhydro-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-D-glucitol
• <span class="text-smallcaps">D</span>-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-, (1S)-
• Bms-512148
• D-Glucitol, 1,5-Anhydro-1-C-[4-Chloro-3-[(4-Ethoxyphenyl)Methyl]Phenyl]-, (1S)-
• Dapagliflozin
• Dapagliflozin free base
• (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

(2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}-6-(hydroxymethyl)oxane-3,4,5-triol

CAS: 461432-26-8

Formula: C₂₁H₂₅ClO₆

Purity: 97%

Color and Shape: Solid

Molecular weight: 408.8726

Ref: IN-DA0039GJ

Dapagliflozin-13C6 (Glucitol-13C6)

CAS: 461432-26-8

Formula: C₁₅₁₃C₆H₂₅ClO₆

Molecular weight: 414.83

Ref: 4Z-D-6251

Dapagliflozin

CAS: 461432-26-8

Formula: C₂₁H₂₅ClO₆

Color and Shape: White To Off-White Solid

Molecular weight: 408.88

Ref: 4Z-D-623

Dapagliflozin

CAS: 461432-26-8

Dapagliflozin

Purity: ≥98%

Molecular weight: 408.87g/mol

Ref: 54-BUP13385

Dapagliflozin-13C6

CAS: 461432-26-8

Formula: C₁₅₁₃C₆H₂₅ClO₆

Molecular weight: 414.83

Ref: 4Z-D-6220

Dapagliflozin

CAS: 461432-26-8

Formula: C₂₁H₂₅ClO₆

Purity: ≥ 98.0% (dried basis)

Color and Shape: White to light-yellow powder

Molecular weight: 408.87

Ref: 7W-GP5853

Dapagliflozin

CAS: 461432-26-8

Dapagliflozin

Purity: 98%

Molecular weight: 408.87g/mol

Ref: 54-OR1030481

Dapagliflozin

CAS: 461432-26-8

Formula: C₂₁H₂₅ClO₆

Purity: >95.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 408.88

Ref: 3B-D6234

Dapagliflozin

CAS: 461432-26-8

Color and Shape: Neat

Ref: 04-C11962000

Dapagliflozin

CAS: 461432-26-8

Formula: C₂₁H₂₅ClO₆

Color and Shape: White To Light Yellow

Molecular weight: 408.87

Ref: 86-MM3611.04

Dapagliflozin-d7

CAS: 461432-26-8

Formula: C₂₁H₁₈ClO₆D₇

Molecular weight: 415.93

Ref: 4Z-D-622

Dapagliflozin

CAS: 461432-26-8

Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.

Formula: C₂₁H₂₅ClO₆

Purity: 99.5% - 99.93%

Color and Shape: Solid

Molecular weight: 408.87

Ref: TM-T2389

DAPAGLIFLOZIN

CAS: 461432-26-8

Purity: 98%

Molecular weight: 408.8800048828125

Ref: 10-F794039

Dapagliflozin

CAS: 461432-26-8

Stability Hygroscopic
Applications A sodium-glucose transporter 2 inhibitor.
References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011)

Formula: C₂₁H₂₅ClO₆

Color and Shape: Neat

Molecular weight: 408.87

Ref: TR-D185370

Dapagliflozin - Bio-X ™

CAS: 461432-26-8

Dapagliflozin is a sodium-glucose cotransporter subtype 2 (SGLT2) inhibitor that can be used in the treatment of diabetes mellitus type 2. It inhibits glucose reabsorption in the proximal tubule of the nephron and results in glycosuria, which helps to improve glycaemic control. Also, Dapagliflozin is used to lower the risk of sustained eGFR decline, end-stage renal disease, cardiovascular death, and hospitalization for heart failure in patients with chronic kidney disease who are at risk of progression.

Formula: C₂₁H₂₅ClO₆

Purity: Min. 99 Area-%

Color and Shape: Powder

Molecular weight: 408.87 g/mol

Ref: 3D-BD164346

Dapagliflozin

CAS: 461432-26-8

Dapagliflozin is a sodium-glucose cotransporter subtype 2 (SGLT2) inhibitor that can be used in the treatment of diabetes mellitus type 2. SGLT2 is located in the proximal convoluted tubule and when it is inhibited the reabsorption of glucose into the kidneys is prevented and instead glucose is excreted in the urine. As a result glucose levels are reduced. Dapagliflozin is metabolized into to its inactive metabolite 3-O-glucuronide by the UGT1A9 enzyme present in the liver and the kidneys. In addition, dapagliflozin has been shown to cause weight loss and decrease the risk of cardiovascular events such as congestive heart failure.

Formula: C₂₁H₂₅ClO₆

Purity: Min. 98 Area-%

Color and Shape: White Yellow Powder

Molecular weight: 408.87 g/mol

Ref: 3D-MD20795