CAS 461443-59-4

Aplaviroc

Description:

Aplaviroc is a chemical compound that belongs to the class of antiretroviral drugs, specifically designed to inhibit the replication of HIV (Human Immunodeficiency Virus). It functions primarily as a CCR5 antagonist, blocking the CCR5 co-receptor on the surface of T-cells, which HIV uses to enter and infect these immune cells. This mechanism of action helps to prevent the virus from establishing an infection and reduces viral load in patients. Aplaviroc has been studied for its potential effectiveness in treating HIV, particularly in individuals with CCR5-tropic strains of the virus. The compound has a relatively complex molecular structure, which contributes to its pharmacological properties. While it has shown promise in clinical trials, its development has faced challenges, leading to limited availability in the market. As with many antiretroviral therapies, potential side effects may include gastrointestinal disturbances, liver enzyme elevations, and hypersensitivity reactions. Overall, Aplaviroc represents an important avenue in the ongoing effort to combat HIV/AIDS.

Formula: C₃₃H₄₃N₃O₆

InChI: InChI=1S/C33H43N3O6/c1-2-3-19-36-30(38)28(29(37)24-7-5-4-6-8-24)34-32(41)33(36)17-20-35(21-18-33)22-23-9-13-26(14-10-23)42-27-15-11-25(12-16-27)31(39)40/h9-16,24,28-29,37H,2-8,17-22H2,1H3,(H,34,41)(H,39,40)/t28-,29-/m1/s1

InChI key: InChIKey=GWNOTCOIYUNTQP-FQLXRVMXSA-N

SMILES: C(CCC)N1C2(C(=O)N[C@]([C@H](O)C3CCCCC3)(C1=O)[H])CCN(CC4=CC=C(OC5=CC=C(C(O)=O)C=C5)C=C4)CC2

Synonyms:

• 4-[4-[[(3R)-1-Butyl-3-[(R)-cyclohexylhydroxymethyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl]methyl]phenoxy]benzoic acid
• Ak 602
• Aplaviroc
• Apliviroc
• Benzoic acid, 4-[4-[[(3R)-1-butyl-3-[(R)-cyclohexylhydroxymethyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl]methyl]phenoxy]-
• Benzoic acid, 4-[4-[[1-butyl-3-[(R)-cyclohexylhydroxymethyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl]methyl]phenoxy]-
• Gsk 873140
• Gw 873140
• Ono 4128

Aplaviroc

CAS: 461443-59-4

Aplaviroc

Purity: ≥95%

Molecular weight: 577.71g/mol

Ref: 54-BUP04718

Aplaviroc

CAS: 461443-59-4

Inhibits chemokine receptor CCR5; anti-viral activity against HIV

Formula: C₃₃H₄₃N₃O₆

Purity: Min. 95%

Molecular weight: 577.71 g/mol

Ref: 3D-BA166505

Aplaviroc

CAS: 461443-59-4

Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.

Formula: C₃₃H₄₃N₃O₆

Purity: 97.98% - 98.26%

Color and Shape: Solid

Molecular weight: 577.71

Ref: TM-T14307