Sordarin sodium salt is a chemical compound derived from sordarin, a natural product known for its antifungal properties. It is typically characterized by its ability to inhibit the growth of various fungi, making it of interest in pharmaceutical applications, particularly in the treatment of fungal infections. The sodium salt form enhances its solubility in aqueous solutions, which is beneficial for biological activity and formulation in medicinal products. Sordarin sodium salt exhibits a specific mechanism of action by interfering with protein synthesis in fungal cells, thereby exerting its antifungal effects. Additionally, it may possess other biological activities, although research is ongoing to fully elucidate its pharmacological profile. The compound's stability, solubility, and bioavailability are critical factors that influence its efficacy in therapeutic applications. As with many chemical substances, safety and toxicity profiles are essential considerations in its development and use, necessitating thorough evaluation in preclinical and clinical studies.

Sordarin is an inhibitor of fungal protein synthesis originally isolated from
S. araneosa
. It binds to elongation factor 2 (EF-2) in the presence of ribosomes and inhibits the uncoupled GTPase activity of equimolar mixtures of EF-2 and ribosomes from
C. albicans
(IC
50
= 0.1 μM). Sordarin inhibits protein synthesis in cell-free lysates of
C. albicans
,
C. glabrata
, and
C. neoformans
(IC
50
s = 0.01, 0.2, and 0.06 μg/ml, respectively) but not in rabbit reticulocytes (IC
50
= >100 μg/ml). It inhibits the growth of
C. albicans
(MIC = 8 μg/ml) but not
C. glabrata
or
C. neoformans
(MICs = >125 μg/ml).

sordarin sodium salt

463356-00-5: Sordarin sodium salt is a chemical compound derived from sordarin, a natural product known for its antifungal properties. It is typically characterized by its ability to inhibit the growth of various fungi, making it of interest in pharmaceutical applications, particularly in the treatment of fungal infections. The sodium salt form enhances its solubility in aqueous solutions, which is beneficial for biological activity and formulation in medicinal products. Sordarin sodium salt exhibits a specific mechanism of action by interfering with protein synthesis in fungal cells, thereby exerting its antifungal effects. Additionally, it may possess other biological activities, although research is ongoing to fully elucidate its pharmacological profile. The compound's stability, solubility, and bioavailability are critical factors that influence its efficacy in therapeutic applications. As with many chemical substances, safety and toxicity profiles are essential considerations in its development and use, necessitating thorough evaluation in preclinical and clinical studies.

<p>Sordarin, from S. araneosa, inhibits fungal EF-2 protein synthesis; effective against C. albicans with varying potency on other species.</p>

Sordarin sodium

<p>Sordarin sodium salt is an antifungal agent, characterized as a semisynthetic derivative produced from the fermentation products of filamentous fungi, specifically belonging to the phylum Ascomycota. This compound exerts its effects by selectively inhibiting fungal protein synthesis. It achieves this by obstructing the function of elongation factor 2 (EF-2), an essential component of fungal ribosomal activity, thereby disrupting the translational elongation step of protein synthesis.</p>

CAS 463356-00-5

sordarin sodium salt

Sordarin sodium

Ref: TM-T36434

Sordarin sodium salt

Ref: 3D-FS162253