CAS 464-74-4

Arenobufagin

Description:

Arenobufagin is a naturally occurring bufadienolide, a type of cardiac glycoside, primarily derived from the skin of certain toads, particularly the Chinese toad (Bufo gargarizans). It is characterized by its steroid-like structure, which includes a lactone ring and multiple hydroxyl groups, contributing to its biological activity. Arenobufagin exhibits potent pharmacological effects, particularly in the cardiovascular system, where it can influence heart contractility and rhythm. It has been studied for its potential therapeutic applications, including anti-cancer properties and effects on various cellular processes. However, it is also associated with toxicity, as it can lead to arrhythmias and other adverse effects when misused or overdosed. The compound's mechanism of action involves the inhibition of Na+/K+ ATPase, leading to increased intracellular calcium levels, which enhances cardiac contractility. Due to its potent effects and potential toxicity, careful handling and dosage considerations are essential in any therapeutic context. As with many natural products, further research is ongoing to fully understand its mechanisms and potential applications in medicine.

Formula: C₂₄H₃₂O₆

InChI: InChI=1S/C24H32O6/c1-22-9-7-15(25)11-14(22)4-5-17-19(22)20(27)21(28)23(2)16(8-10-24(17,23)29)13-3-6-18(26)30-12-13/h3,6,12,14-17,19-20,25,27,29H,4-5,7-11H2,1-2H3/t14-,15+,16-,17-,19-,20+,22+,23+,24+/m1/s1

InChI key: InChIKey=JGDCRWYOMWSTFC-AZGSIFHYSA-N

SMILES: C[C@@]12[C@@](O)([C@]3([C@]([C@H](O)C1=O)([C@]4(C)[C@](CC3)(C[C@@H](O)CC4)[H])[H])[H])CC[C@@H]2C=5C=CC(=O)OC5

Synonyms:

• (3β,5β,11α)-3,11,14-Trihydroxy-12-oxobufa-20,22-dienolide
• 5β-Bufa-20,22-dienolide, 3β,11α,14-trihydroxy-12-oxo-
• Arenobufagin
• Bufa-20,22-dienolide, 3,11,14-trihydroxy-12-oxo-, (3β,5β,11α)-

Arenobufagin

CAS: 464-74-4

Formula: C₂₄H₃₂O₆

Purity: 95%

Molecular weight: 416.5073

Ref: IN-DA00DB84

Arenobufagin

CAS: 464-74-4

Arenobufagin

Purity: ≥98%

Molecular weight: 416.51g/mol

Ref: 54-BUP12654

Arenobufagin

CAS: 464-74-4

Formula: C₂₄H₃₂O₆

Molecular weight: 416.51

Ref: 7W-GY3973

Arenobufagin

CAS: 464-74-4

Arenobufagin is a potent Na + /K + pump inhibitor, and is also a specific inhibitor of VEGF-mediated angiogenesis. Arenobufagin has antineoplastic effect that involves cross talk between apoptosis and autophagy via inhibition of the PI3K/Akt/mTOR pathway.

Formula: C₂₄H₃₂O₆

Purity: 95%~99%

Molecular weight: 416.514

Ref: BP-BP0190

Arenobufagin

CAS: 464-74-4

Arenobufagin is a natural bufadienolide from toad venom with potent antineoplastic activity against HCC HepG2 cells and corresponding multidrug-resistant HepG2/

Formula: C₂₄H₃₂O₆

Purity: 99.14% - 99.8%

Color and Shape: Solid

Molecular weight: 416.51

Ref: TM-T5A2455

Arenobufagin

CAS: 464-74-4

Arenobufagin is a natural compound that has been shown to have anticancer properties. It has been shown to inhibit the proliferation of cancer cells and induce apoptosis in vitro. Arenobufagin also has anti-inflammatory effects and can be used as an antimicrobial agent, particularly against infectious diseases. Arenobufagin inhibits the formation of liver cancer cells by interfering with lipid metabolism. It binds to the polymerase chain reaction (PCR) enzyme, preventing DNA replication and leading to cell death. Arenobufagin also inhibits mitochondrial membrane potential, which leads to the loss of mitochondrial membrane potential and subsequent cell death. Structural analysis shows that aren’tnobufagin binds specifically to caspases, which are enzymes responsible for initiating apoptosis in cells.

Formula: C₂₄H₃₂O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 416.51 g/mol

Ref: 3D-FA74189