CAS 464193-92-8

Fmoc-trans-4-hydroxy-D-proline tert-butyl ester

Description:

Fmoc-trans-4-hydroxy-D-proline tert-butyl ester is a chemical compound that serves as a valuable building block in peptide synthesis and medicinal chemistry. It features a tert-butyl ester group, which enhances its lipophilicity and stability, making it suitable for various synthetic applications. The Fmoc (9-fluorenylmethoxycarbonyl) protecting group is commonly used in solid-phase peptide synthesis, allowing for selective deprotection under mild conditions. The trans configuration of the proline residue is significant as it influences the conformational properties of peptides, impacting their biological activity and stability. This compound is typically characterized by its solid-state form, with a specific melting point range, and it is soluble in organic solvents such as dichloromethane and dimethylformamide. Its molecular structure includes a hydroxyl group, which can participate in hydrogen bonding, further affecting its reactivity and interactions in biological systems. Overall, Fmoc-trans-4-hydroxy-D-proline tert-butyl ester is an important reagent in the field of organic synthesis and peptide chemistry.

Formula: C₂₄H₂₇NO₅

Synonyms:

• Fmoc-D-Hyp(tbu)-OH
• N-(9-Fluorenylmethoxycarbonyl)-trans-4-hydroxy-D-proline tert-butyl ester
• (2S,4S)-1-(((9H-fluoren-9-yl)Methoxy)carbonyl)-4-tert-butoxypyrrolidine-2-carboxylic acid
• FMOC-CIS-4-TERT-BUTOXY-L-PROLINE
• Fmoc-O-tert-butyl-D-4-hydroxyproline
• FMOC-D-HYDROXYPROLINE(TBU)-OH
• Fmoc-cis-L-hyp(tbu)-oh
• FMOC-D-HYP(TBU)-OH USP/EP/BP
• (2S,4S)-4-(tert-butoxy)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-2-carboxylic acid
• Fmoc-trans-4-hydroxy-D-proline tert-butyl ester
• N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-T-BUTYL-TRANS-4-HYDROXY-D-PROLINE
• 1,2-Pyrrolidinedicarboxylic acid, 4-(1,1-dimethylethoxy)-, 1-(9H-fluoren-9-ylmethyl) ester, (2S,4S)-
• (9H-Fluoren-9-yl)MethOxy]Carbonyl cis-L-Hyp(tBu)-OH
• FMOC-O-T-BUTYL-D-TRANS-4-HYDROXYPROLINE

FMOC-D-HYP(TBU)-OH

CAS: 464193-92-8

Formula: C₂₄H₂₇NO₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 409.4749

Ref: IN-DA0072F4

Fmoc-D-Hyp(tBu)-OH

CAS: 464193-92-8

Fmoc-D-Hyp(tBu)-OH

Purity: 98%

Molecular weight: 409.47g/mol

Ref: 54-OR1033491

N-Fmoc-cis-4-tert-butoxy-L-Proline

CAS: 464193-92-8

Formula: C₂₄H₂₇NO₅

Molecular weight: 409.48

Ref: 4Z-P-166063

(2S,4S)-4-(tert-butoxy)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-2-carboxylic acid

CAS: 464193-92-8

Formula: C₂₄H₂₇NO₅

Purity: 95%

Molecular weight: 409.482

Ref: 10-F548267

Fmoc-D-Hyp(tBu)-OH

CAS: 464193-92-8

Fmoc-D-Hyp(tBu)-OH is a carbonyl compound that belongs to the class of glycopeptide. It has been shown to have anti-cancer activity against thp-1 cells, which are derived from human acute promyelocytic leukemia cells. Fmoc-D-Hyp(tBu)-OH inhibits cell proliferation and induces apoptosis in thp-1 cells. This chemical has also been shown to inhibit the production of collagen, an important component of blood vessel walls, by inhibiting the activity of lysyl hydroxylase. The biological function of this drug is not fully understood but it may be related to autophagy and asymmetric synthesis.

Formula: C₂₄H₂₇NO₅

Purity: Min. 95%

Molecular weight: 409.47 g/mol

Ref: 3D-PTA19392