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CAS 4647-20-5

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Icomethasone

Description:
Icomethasone, with the CAS number 4647-20-5, is a synthetic corticosteroid that exhibits anti-inflammatory and immunosuppressive properties. It is primarily used in the treatment of various inflammatory conditions, including skin disorders and allergic reactions. The substance functions by mimicking the effects of naturally occurring hormones produced by the adrenal glands, thereby modulating the immune response and reducing inflammation. Icomethasone is characterized by its ability to inhibit the release of inflammatory mediators and suppress the activity of immune cells. Its pharmacological effects are attributed to its interaction with glucocorticoid receptors, leading to alterations in gene expression. While effective in managing symptoms, the use of Icomethasone may be associated with potential side effects, including skin thinning, hormonal imbalances, and increased susceptibility to infections, particularly with prolonged use. As with any corticosteroid, careful consideration of dosage and duration of treatment is essential to minimize adverse effects while maximizing therapeutic benefits.
Formula:C22H29ClO5
InChI:InChI=1S/C22H29ClO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChI key:InChIKey=NBMKJKDGKREAPL-CXSFZGCWSA-N
SMILES:Cl[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(CO)=O)(O)[C@H](C)C3)[H])(CCC=4[C@]2(C)C=CC(=O)C4)[H]
Synonyms:
  • Pregna-1,4-diene-3,20-dione, 9-chloro-11,17,21-trihydroxy-16-methyl-, (11β,16α)-
  • Icometasone
  • Pregna-1,4-diene-3,20-dione, 9-chloro-11β,17,21-trihydroxy-16α-methyl-
  • Icomethasone
  • (11β,16α)-9-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
  • (8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
  • Mometasone Furoate Impurity 13
  • (8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
  • Mometasone Furoate EP Impurity K (Icomethasone)
  • Mometasone EP Impurity K
  • See more synonyms
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