CAS 465-16-7
:Oleandrin
Description:
Oleandrin is a toxic cardiac glycoside primarily derived from the Nerium oleander plant, commonly known as oleander. It is characterized by its ability to inhibit the sodium-potassium ATPase enzyme, which can lead to increased intracellular sodium and calcium levels, ultimately affecting cardiac contractility. Oleandrin exhibits a structure that includes a steroid nucleus with a sugar moiety, contributing to its biological activity. The substance is known for its potential medicinal properties, including anti-cancer and anti-inflammatory effects, although its toxicity poses significant risks, particularly in overdose situations. Symptoms of oleandrin poisoning can include gastrointestinal distress, arrhythmias, and even death. Due to its toxic nature, oleandrin is not approved for therapeutic use in many regions, and caution is advised when handling or using products derived from oleander. Research continues into its pharmacological potential, but safety and efficacy remain critical considerations in any therapeutic context.
Formula:C32H48O9
InChI:InChI=1S/C32H48O9/c1-17-29(35)24(37-5)14-27(39-17)41-21-8-10-30(3)20(13-21)6-7-23-22(30)9-11-31(4)28(19-12-26(34)38-16-19)25(40-18(2)33)15-32(23,31)36/h12,17,20-25,27-29,35-36H,6-11,13-16H2,1-5H3/t17-,20+,21-,22-,23+,24-,25-,27-,28-,29-,30-,31+,32-/m0/s1
InChI key:InChIKey=JLPDBLFIVFSOCC-XYXFTTADSA-N
SMILES:O[C@@]12[C@@](C)([C@H]([C@@H](OC(C)=O)C1)C3=CC(=O)OC3)CC[C@]4([C@]2(CC[C@]5([C@]4(C)CC[C@H](O[C@H]6C[C@H](OC)[C@@H](O)[C@H](C)O6)C5)[H])[H])[H]
Synonyms:- (3β,5β,16β)-16-(Acetyloxy)-3-[(2,6-dideoxy-3-O-methyl-α-<span class="text-smallcaps">L</span>-arabino-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide
- (3β,5β,16β)-16-(acetyloxy)-3-[(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide
- 16-beta-acetoxy-3-beta-(2,6-dideoxy-3-O-methyl-L-arabino-hexopyranosyloxy)-14-hydroxycard-20(22)-enolide
- Card-20(22)-enolide, 16-(acetyloxy)-3-[(2,6-dideoxy-3-O-methyl-α-<span class="text-smallcaps">L</span>-arabino-hexopyranosyl)oxy]-14-hydroxy-, (3β,5β,16β)-
- Corrigen
- Foliandrin
- Folinerin
- Neriol
- Neriolin
- Neriostene
- Oleandrigenin 3-O-α-<span class="text-smallcaps">L</span>-oleandroside
- Oleandrine
- Oleandrin
- See more synonyms
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Found 10 products.
Oleandrin
CAS:Oleandrin, a cardiac glycoside, regulates BDNF, inhibits Na/K-ATPase, boosts calcium in heart muscle, and hinders CaCO-2 cell growth.Formula:C32H48O9Purity:98% - 99.94%Color and Shape:Crystals From Dilute Methanol SolidMolecular weight:576.72Oleandrin
CAS:Natural glycosideFormula:C32H48O9Purity:≥ 95.0 % (HPLC)Color and Shape:PowderMolecular weight:576.73Oleandrin
CAS:<p>Applications Cardiotonic; diuretic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sreenivasan, Y., et al.: Biochem. Pharmacol., 66, 2223 (2003), Ni, D., et al.: J. Exp. Ther. Oncol., 2, 278 (2002), Langford, S.D., Toxicology, 109,1 (1996),<br></p>Formula:C32H48O9Color and Shape:White To Off-WhiteMolecular weight:576.72Oleandrin
CAS:<p>Oleandrin is a naturally occurring toxic cardiac glycoside, which is a chemical compound extracted from the leaves and stems of the Nerium oleander plant. Its mode of action involves inhibiting the Na+/K+-ATPase pump, leading to an increase in intracellular sodium concentration and a secondary increase in intracellular calcium levels. This cascade of ion movements enhances cardiac contractility and can disrupt regular cardiac rhythm, which is a hallmark of cardiac glycosides.</p>Formula:C32H48O9Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:576.72 g/mol
