CAS 465-65-6

Naloxone

Description:

Naloxone is an opioid antagonist primarily used to counteract the effects of opioid overdose, particularly respiratory depression. It is a white to off-white crystalline powder that is soluble in water and has a molecular formula of C19H21NO4. Naloxone works by competitively binding to opioid receptors in the brain, effectively reversing the effects of opioids. Its pharmacological action is rapid, typically occurring within minutes when administered intravenously or intranasally. Naloxone has a relatively short half-life, necessitating repeated doses in cases of prolonged opioid exposure. It is generally well-tolerated, with few side effects, although withdrawal symptoms may occur in individuals dependent on opioids. Naloxone is often included in emergency medical kits and is available in various formulations, including injectable and nasal spray forms, making it accessible for use by both healthcare professionals and laypersons in emergency situations. Its role in public health initiatives has been pivotal in reducing opioid-related fatalities.

Formula: C₁₉H₂₁NO₄

InChI: InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1

InChI key: InChIKey=UZHSEJADLWPNLE-GRGSLBFTSA-N

SMILES: O[C@]12[C@@]34C=5C(O[C@]3(C(=O)CC1)[H])=C(O)C=CC5C[C@]2(N(CC=C)CC4)[H]

Synonyms:

• (-)-Naloxone
• (5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propen-1-yl)morphinan-6-one
• 12-Allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4aH-8,9c-iminoethanophenanthro[4,5-bcd]furan-5(6H)-one
• Morphinan-6-one, 17-allyl-4,5α-epoxy-3,14-dihydroxy-
• Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propen-1-yl)-, (5α)-
• Naloxon
• Naloxona
• Normorphinone, N-allyl-7,8-dihydro-14-hydroxy-
• Nsc 70413
• l-Naloxone
• Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5α)-

Naloxone

CAS: 465-65-6

Alkaloids of opium and their derivatives, salts thereof, not elsewhere specified or included

Formula: C₁₉H₂₁NO₄

Color and Shape: Powder

Molecular weight: 327.37

Ref: 45-1453005

Naloxone

CAS: 465-65-6

Applications Naloxone is a specific opioid antagonist. Narcotic antagonist.
References Jasinski, D.R., et al.: J. Pharmacol. Exp. Ther., 157, 420 (1967), McNicholas, L.F., et al.: Drugs, 27, 81 (1984), Hasson, M.M.A., et al.: Anal. Profiles Drug Subs., 14, 453 (1985), Stowe, C., et al.: Ann. Pharmacother., 27, 447 (1993),

Formula: C₁₉H₂₁NO₄

Color and Shape: Neat

Molecular weight: 327.37

Ref: TR-N284995

Naloxone

Controlled Product

CAS: 465-65-6

µ- and Ύ-opioid receptor antagonist; antidote for opioid overdose

Formula: C₁₉H₂₁NO₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 327.37 g/mol

Ref: 3D-FN61467